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Rabbit Anti-NMU Polyclonal Antibody#abs134540

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Description

Catalog-specification	Delivery time	USD price
abs134540-100ug	1-2 Weeks	301.0
abs134540-50ug	1-2 Weeks	201.0

Overview
catalog	abs134540
Other names	Neuromedin U 25, also known as Neuromedin U or NmU 25, is a peptide hormone that plays a significant role in the regulation of various physiological processes in humans. It is a neuropeptide that is primarily produced and secreted by the gastrointestinal tract and the nervous system. NMU_HUMAN is responsible for a wide range of functions, including the regulation of feeding behavior, energy metabolism, cardiovascular function, and stress response. It binds to two different receptors, namely NMU receptor 1 and NMU receptor 2, and triggers a cascade of intracellular signaling pathways that ultimately lead to the activation of various cellular processes. Research has shown that NMU may have significant therapeutic potential in the treatment of obesity, diabetes, and cardiovascular diseases, among others. It has also been implicated in the pathogenesis of certain psychiatric disorders, including anxiety and depression. In conclusion, Neuromedin U 25 is a vital neuropeptide that is involved in the regulation of multiple physiological processes. Further research is needed to fully understand its mechanisms of action and unlock its full therapeutic potential.
Source	Rabbit
Specificity	Total NMU levels can be detected using the NMU Antibody, which targets endogenous levels of the protein. Essentially, the antibody can accurately identify the presence of total NMU in biological samples.
Species Reactivity	Human
Predictive reaction species	Zebrafish;Xenopus;
Antigen	NMU
Application	Western blotting (WB) is usually performed at dilutions ranging from 1:500 to 1:1000. Immunohistochemistry (IHC) is typically carried out at dilutions of 1:50 to 1:200. For immunofluorescence (IF) or immunocytochemistry (ICC), dilutions of 1:100-1:500 are commonly used. ELISA assays using peptides as antigens require higher dilutions, usually within the range of 1:20000 to 1:40000. Please note that the dilution recommendations may vary based on the specific experiment and antibody used.
Immunogen	A synthesized peptide.
MW	22 KD
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. The resulting product is highly refined and of excellent quality.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.
Storage buffer	The Rabbit IgG solution comes in a formulation of phosphate buffered saline with a pH level of 7.4, 150 millimolar of NaCl, 0.02% of sodium azide, and 50% glycerol. It is recommended to store it at a temperature of -20°C to maintain its stability for up to 12 months from the date of purchase.
Target
Background	Stimulates muscle contractions of specific regions of the gastrointestinal tract. In humans, NmU stimulates contractions of the ileum and urinary bladder.
Tissue specificity	Expressed throughout the enteric nervous system with highest levels being found in the jejunum.
Celluar localization	Extracellular region or secreted;
UniPort	P48645