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Rabbit Anti-IGHG1 Polyclonal Antibody#abs137647

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Description

Catalog-specification	Delivery time	USD price
abs137647-100ug	1-2 Weeks	301.0
abs137647-50ug	1-2 Weeks	201.0

Overview
catalog	abs137647
Other names	Ig gamma 1 chain C region, also known as IgG heavy chain locus or IGHG1, is a gene segment responsible for encoding the Immunoglobulin Gm1 protein. This protein is an integral part of the immunoglobulin heavy constant gamma 1, commonly referred to as G1m marker. Its crucial role lies in the immune system's ability to recognize and neutralize harmful substances. By rearranging the provided information, we gain a deeper understanding of the significance and functionality of the IgG heavy chain locus, and how it contributes to our body's defense mechanisms.
Source	Rabbit
Specificity	The IGHG1 Antibody has the ability to recognize and bind to the total endogenous levels of IGHG1. To elaborate on this, the antibody can specifically detect the existence of IGHG1 within an organism or sample. This characteristic of the antibody makes it a valuable tool in numerous scientific applications. It is important to note that the generated content is based on the original information provided.
Species Reactivity	Human
Antigen	IGHG1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human IGHG1.
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve its quality, it is advisable to store the product at a temperature of -20°C for a period of one year without subjecting it to repeated freeze/thaw cycles.
Storage buffer	This product contains Rabbit IgG suspended in a solution of phosphate buffered saline, with a pH of 7.4 and an NaCl concentration of 150mM. It also contains 0.02% sodium azide and 50% glycerol, which are added as stabilizers. To maintain product integrity, storage at temperatures of -20 °C is recommended, and the product is stable for up to 12 months from the date of receipt.
Target
Background	Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P01857