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Rabbit Anti-FRK Polyclonal Antibody#abs133481

Please note that the price provided above is only a reference point. For detailed pricing information, we recommend contacting our seller, Vecent. Western blot analysis of extracts from Jurkat cells, using FRK antibody. This product is for research use only, not for use in diagnostic prodecures...

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Description

Catalog-specification	Delivery time	USD price
abs133481-50ug	1-2 Weeks	201.0
abs133481-100ug	1-2 Weeks	301.0

Please note that the price provided above is only a reference point. For detailed pricing information, we recommend contacting our seller, Vecent.

Overview
catalog	abs133481
Other names	There are various names for the beta cell Src homology tyrosine kinase, including BSK, BSK/IYK, C85044, Frk, Frk fyn related kinase, FRK_HUMAN, FYN related kinase, FYN-related kinase, GASK, Gastrointestinal associated kinase, Gastrointestinal associated tyrosine kinase, GTK, Intestine tyrosine kinase, Nuclear tyrosine protein kinase RAK, Protein-tyrosine kinase 5, PTK5, PTK5 protein tyrosine kinase 5, RAK, Tyrosine protein kinase FRK, Tyrosine-protein kinase FRK. Despite having multiple names, they all refer to the same protein. The beta cell Src homology tyrosine kinase is involved in various cellular processes, including insulin secretion and cell proliferation. It belongs to the family of non-receptor protein-tyrosine kinases and shares similar characteristics with other members of the family, such as Fyn and Yes. Scientists have studied its function in different tissues, including the gastrointestinal tract and the pancreas. Despite its vital role in cellular signaling, much remains to be learned about this protein's function and potential therapeutic applications.
Source	Rabbit
Specificity	Total FRK levels can be effectively detected by the FRK Antibody, which specifically targets the endogenous FRK protein.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Bovine;Pig;Sheep
Antigen	FRK
Application	The dilution range for WB is 1:500 to 1:1000, while for IHC it is 1:50 to 1:200. For IF/ICC, the dilution range is 1:100 to 1:500. Lastly, for ELISA (peptide), the dilution range is 1:20000 to 1:40000. Please note that the information provided is based on the original text and rearranged to form a similar content.
Immunogen	A synthesized peptide.
MW	55 KD
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin in the peptide affinity chromatography process to purify the antiserum. This method allowed for the efficient purification of the antiserum based on the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to keep it stored at a temperature of -20°C for a period of one year. Repeated freeze/thaw cycles should be avoided as this can have a negative impact on the product. It is important to note that maintaining proper storage conditions is crucial for ensuring that the product remains stable and effective over time. Therefore, it is advisable to follow the storage instructions provided to achieve optimal results.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
Tissue specificity	Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.
Celluar localization	Cytosol;Extracellular region or secreted;Lysosome;Nucleus;Plasma Membrane;
UniPort	P42685