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Rabbit Anti-GSTP1 Polyclonal Antibody#abs136974

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Description

Catalog-specification	Delivery time	USD price
abs136974-100ug	1-2 Weeks	301.0
abs136974-50ug	1-2 Weeks	201.0

Overview
catalog	abs136974
Other names	DFN7, also known as Deafness X linked 7, is a genetic disorder that affects hearing. It is caused by mutations in the Fatty Acid Ethyl Ester Synthase III (FAEES3) gene, which codes for the enzyme glutathione S-transferase pi 1 (GSTP1). This enzyme plays an important role in protecting cells from oxidative stress and toxins by metabolizing a variety of compounds. Individuals with DFN7 may experience varying degrees of hearing loss, which can range from mild to profound. The disorder is inherited in an X-linked recessive manner, which means that it occurs more frequently in males than in females.
Source	Rabbit
Specificity	Total GSTP1 levels can be detected using the GSTP1 antibody, which specifically targets endogenous levels of the protein. The antibody is highly effective in detecting GSTP1 and can provide reliable results in various research applications. Its ability to precisely measure the levels of total GSTP1 makes it an important tool for understanding the functions of this protein in different biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Rabbit;Bovine;Dog
Antigen	GSTP1
Application	The recommended dilutions for WB are between 1:500 to 1:2000, while for IHC, it ranges from 1:50 to 1:200. For ELISA using peptide, the suggested dilution is between 1:20000 to 1:40000. It is important to strictly adhere to these recommended dilutions to achieve optimal results.
Immunogen	A synthesized peptide derived from human GSTP1.
MW	23kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification of the antiserum through peptide affinity chromatography. The process aimed to isolate the desired protein molecules from the mixture.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage condition for a year is at -20 °C. It is important to avoid subjecting the stored item to repeated freeze/thaw cycles.
Storage buffer	This product consists of Rabbit IgG that has been dissolved in phosphate buffered saline with a pH of 7.4, 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store this product at a temperature of -20°C, where it remains stable and usable for up to 12 months from the date of receipt.
Target
Background	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
Celluar localization	Cytosol;Extracellular region or secreted;Mitochondrion;Nucleus;Plasma Membrane;
UniPort	P09211