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Rabbit Anti-GPM6A Polyclonal Antibody#abs139219

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Description

Catalog-specification	Delivery time	USD price
abs139219-100ug	1-2 Weeks	301.0
abs139219-50ug	1-2 Weeks	201.0

Overview
catalog	abs139219
Other names	Neuronal membrane glycoprotein M6-a, also known as GPM6A or M6a, is an important protein involved in regulating cellular processes in the brain and nervous system. This membrane protein is highly expressed in neurons and is essential for proper neural development and function. Through its interactions with other proteins and lipids, GPM6A modulates various signaling pathways that are critical for maintaining the integrity of brain circuits and facilitating communication between neurons. Understanding the role of GPM6A in neural function could provide insights into how to treat a range of neurological disorders, including Alzheimer's disease and schizophrenia.
Source	Rabbit
Specificity	The GPM6A Antibody is designed to specifically target and measure the levels of total GPM6A in the body. It is capable of detecting the endogenous levels of this protein. By using this antibody, researchers can accurately analyze and understand the role and functions of GPM6A in various biological processes.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Rabbit;Pig;Dog;Sheep;Bovine;Horse
Antigen	GPM6A
Application	The recommended dilutions for WB are between 1:1000 to 1:3000, while for IHC it is suggested to use a dilution of 1:200. For ELISA using peptide antigens, the range of optimal dilutions is between 1:20000 to 1:40000. It is important to note that these dilutions may vary depending on the quality of the antibody and antigen used, as well as the experimental conditions. Therefore, it is recommended to perform a titration to determine the optimal dilution for each individual experiment.
Immunogen	A synthesized peptide derived from human GPM6A.
MW	31 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the purification process of the antiserum via peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended that you keep the product in a freezer set to a temperature of -20°C. This is the ideal range for maintaining the stability and integrity of the product. It is important to note that you should avoid exposing the product to repeated freeze/thaw cycles which can negatively impact the quality and efficacy. For best results, store the product at -20°C for up to one year.
Storage buffer	Phosphate buffered saline containing Rabbit IgG is stored at -20 °C and has a stability period of 12 months from the date of receipt. The solution is prepared in pH 7.4 and includes 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to store the solution under these conditions to maintain its integrity and effectiveness.
Target
Background	Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P51674