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Rabbit Anti-Gelsolin Polyclonal Antibody#abs137188

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Description

Catalog-specification	Delivery time	USD price
abs137188-100ug	1-2 Weeks	301.0
abs137188-50ug	1-2 Weeks	201.0

Dear valued customer,
Please note that the price mentioned is only for your reference. In order to get the detailed price, we kindly request you to contact our seller, Vecent.
Thank you for your understanding.

Overview
catalog	abs137188
Other names	Gelsolin, also known as actin depolymerizing factor (ADF), actin-depolymerizing factor, and AGEL, is a protein that plays a key role in the regulation of actin dynamics. It is encoded by the GSN gene and is sometimes referred to as brevin or DKFZp313L0718. The ADF family of proteins, of which gelsolin is a member, is involved in various cellular processes, including cell migration, cell division, and phagocytosis. These proteins help to regulate actin filament assembly and disassembly, which is critical for many cellular functions. Gelsolin has been found to be involved in several human diseases, including Alzheimer's disease and cancer. In particular, gelsolin has been shown to have anti-tumor properties and may offer potential therapeutic benefits for cancer patients. Overall, the study of gelsolin and the ADF family of proteins is important for understanding the basic biology of cells and for developing new treatments for various diseases.
Source	Rabbit
Specificity	The total Gelsolin in the system can be accurately measured using the Gelsolin Antibody, which is specifically designed to detect the endogenous levels of Gelsolin.
Species Reactivity	Human
Antigen	Gelsolin
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human Gelsolin.
MW	86 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized to perform peptide affinity chromatography for the purification of the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it in a freezer at a temperature of -20 °C for up to a year. However, it is advisable to avoid subjecting the product to repeated cycles of freezing and thawing as this may affect its integrity.
Storage buffer	The Rabbit IgG is stored in a solution of phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is advised to store it at a temperature of -20 °C. The product remains stable for a period of 12 months starting from the date of receipt.
Target
Background	This protein is involved in regulating calcium levels and modulating actin assembly. It specifically binds to the plus ends of actin filaments and blocks the exchange of actin monomers. Additionally, it has the ability to stimulate the assembly of new filamentous structures and can also sever pre-existing filaments. This versatile protein plays an important role in ciliogenesis.
Tissue specificity	Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells.
Posttranslational modification	Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Plasma Membrane;
UniPort	P06396