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Rabbit Anti-GALNS Polyclonal Antibody#abs136863

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Description

Catalog-specification	Delivery time	USD price
abs136863-100ug	1-2 Weeks	301.0
abs136863-50ug	1-2 Weeks	201.0

Overview
catalog	abs136863
Description	The N-acetylgalactosamine-6-sulfatase gene is responsible for encoding a crucial lysosomal enzyme that aids in the breakdown of glycosaminoglycans like keratan sulfate and chondroitin 6-sulfate. When there are alterations in the gene, such as mutations or splicing errors, this can lead to a deficiency of the enzyme which in turn causes Morquio A syndrome, a type of lysosomal storage disorder. The deficiency hinders the efficient breakdown of glycosaminoglycans within the body, leading to a host of problems for those affected by the syndrome.
Other names	There are a variety of names and terms associated with the enzyme known as chondroitinase or chondroitinsulfatase. Some alternative names for the enzyme include FLJ00319, FLJ17434, FLJ42844, and FLJ98217. Additionally, the enzyme is sometimes referred to as galactosamine (N acetyl) 6 sulfate sulfatase, galactose 6 sulfate sulfatase, GALNAC6S, or GalNAc6S sulfatase. Another potential name for chondroitinase is GALNS6 or GAS. The enzyme is also sometimes referred to as mFLJ00319 or MPS4A, as these names are associated with specific variants or forms of the enzyme. Ultimately, regardless of the specific name or term used, chondroitinase or chondroitinsulfatase refers to an important enzyme involved in the breakdown and metabolism of chondroitin sulfate in the body.
Source	Rabbit
Specificity	The total GALNS present in the body can be effectively detected by using the GALNS Antibody, which is specifically designed to target and identify endogenous levels of this protein.
Species Reactivity	Human;Mouse;Rat
Antigen	GALNS
Application	The suggested dilution range for WB is 1:500-1:2000, while for IHC it is 1:50-1:200. For ELISA using a peptide, the recommended dilution range is 1:20000-1:40000. To summarize, the antibody should be appropriately diluted based on the application to achieve optimal results. It is essential to follow the recommended range to avoid over-dilution or under-dilution, leading to inaccurate results.
Immunogen	A synthesized peptide derived from human GALNS.
MW	58kDa
Properties
Concentration	1mg/ml
purification	Using the SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate.
Posttranslational modification	The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Celluar localization	Extracellular region or secreted;Lysosome;
UniPort	P34059