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Rabbit Anti-FGF19 Polyclonal Antibody#abs133030

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Description

Catalog-specification	Delivery time	USD price
abs133030-100ug	1-2 Weeks	301.0
abs133030-50ug	1-2 Weeks	201.0

Overview
catalog	abs133030
Description	The down-regulation of CYP7A1 expression is involved in the suppression of bile acid biosynthesis. This process is stimulated by the positive regulation of the JNK and ERK1/2 cascades. In adipocytes, it also stimulates glucose uptake. It's important to note that the presence of KLB is required for its activity.
Other names	FGF 19, also known as FGF-19 or FGF15, is a protein encoded by the FGF19 gene in humans. It belongs to the fibroblast growth factor family and plays a crucial role in various biological processes. FGF-19 has been identified as a key regulator of bile acid synthesis and metabolism. It is primarily expressed in the liver and acts as an endocrine hormone. FGF19_HUMAN is the official gene symbol used to represent this protein in scientific publications. Its discovery has garnered significant interest due to its potential therapeutic applications in treating metabolic disorders such as obesity and type 2 diabetes. The research on FGF-19 continues to unravel its precise mechanism of action and explore its therapeutic potential in various diseases.
Source	Rabbit
Specificity	The FGF19 antibody is specifically designed to recognize and bind to the total endogenous levels of FGF19. Its ability to detect the protein in its native form makes it an ideal tool for research investigations aimed at exploring the biological functions of FGF19 in various biological processes. Using this antibody, researchers can effectively study the role of FGF19 in cellular signaling pathways and other physiological mechanisms. Overall, the FGF19 antibody has proven to be a reliable and effective tool in the study of FGF19-mediated protein interactions and functional analyses.
Species Reactivity	Human;Rat
Antigen	FGF19
Application	The recommended dilutions for using this specific antibody in different applications are as follows: for Western blotting, the suggested dilutions range from 1:500 to 1:2000. For immunohistochemistry, dilutions of 1:50 to 1:200 are recommended. Finally, for ELISA using peptides, dilutions of 1:20000 to 1:40000 are suggested for optimal results. It is important to use the appropriate dilutions for each application to ensure accurate and reliable results.
Immunogen	A synthesized peptide.
MW	24 kDa;;
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin in peptide affinity chromatography to purify the antiserum. Please rearrange the content to generate a similar but distinct piece of text based on the original information provided.
Clonality	Polyclonal Antibody
Stability & Storage	The suggested storage condition for a duration of one year is at -20 °C. It is crucial to prevent repeated freeze/thaw cycles.
Storage buffer	The solution contains 50% glycerol, Rabbit IgG suspended in phosphate buffered saline at pH 7.4, with 150mM NaCl and 0.02% sodium azide.
Target
Background	Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
Tissue specificity	Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Celluar localization	Extracellular region or secreted;
UniPort	O95750