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Rabbit Anti-TP53INP1 Polyclonal Antibody#abs138251

Description

Catalog-specification	Delivery time	USD price
abs138251-100ug	1-2 Weeks	301.0
abs138251-50ug	1-2 Weeks	201.0

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Overview
catalog	abs138251
Other names	TP53INP1, also known as p53-dependent damage-inducible nuclear protein 1 or p53 inducible nuclear protein 1, is a stress-induced protein that plays a role in cellular responses to DNA damage. It is encoded by the DKFZp434M1317 and FLJ22139 genes in humans. TP53INP1 is also referred to as Tumor protein p53 inducible nuclear protein 1 or simply Teap. This protein is activated by the p53 tumor suppressor protein and is involved in p53-mediated cellular stress responses. It functions as a transcriptional regulator, modulating the expression of genes involved in cell cycle arrest, apoptosis, and DNA repair. TP53INP1 has been implicated in various cellular processes, including autophagy, oxidative stress response, and senescence. In addition to its role in DNA damage response, TP53INP1 has been associated with cancer development and progression. It has been shown to have both tumor suppressor and oncogenic properties, depending on the cellular context. Aberrant expression or dysfunction of TP53INP1 has been observed in several types of cancer, including breast, prostate, and lung cancer. Overall, TP53INP1 is a versatile protein that plays a critical role in maintaining genomic stability and regulating cellular responses to stress. Further research on its mechanisms of action and clinical implications may provide valuable insights for cancer prevention and treatment strategies.
Source	Rabbit
Specificity	The TP53INP1 Antibody is specifically designed to identify the total TP53INP1 protein present in the body. It has the capability to detect the endogenous levels of TP53INP1 accurately.
Species Reactivity	Human;Mouse
Predictive reaction species	Rabbit;Sheep;Dog;Horse;Bovine
Antigen	TP53INP1
Application	I can generate a rearranged content based on the original text information. Here it is: - For western blotting, the suggested dilution range is 1:1000-3000. - When performing immunofluorescence or immunocytochemistry, it is recommended to use a dilution of 1:100-1:500. - In ELISA assays using peptides, a dilution of 1:20000-1:40000 is suggested for optimal results.
Immunogen	A synthesized peptide derived from human TP53INP1.
MW	27 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed for peptide affinity chromatography to purify the antiserum. Let's create a highly similar version by rearranging the given information.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, it is recommended that this product be kept at a temperature of -20°C for up to one year. It is important to avoid exposing the product to repeated freeze/thaw cycles, as this may compromise its quality and effectiveness. By following these guidelines, you can help ensure that this product remains stable and effective for its intended use.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
Tissue specificity	Ubiquitously expressed.
Celluar localization	Cytosol;Nucleus;
UniPort	Q96A56