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Rabbit Anti-Erbin Polyclonal Antibody#abs138064

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Description

Catalog-specification	Delivery time	USD price
abs138064-100ug	1-2 Weeks	301.0
abs138064-50ug	1-2 Weeks	201.0

Overview
catalog	abs138064
Other names	Erbin, also known as Erbb2-interacting protein or Erbb2ip, is a protein that is highly similar to Densin-180-like protein. It is also referred to as LAP2 or Protein LAP2. This protein interacts with the ErbB2 receptor and is involved in the regulation of cell proliferation and differentiation. Erbin plays an important role in the maintenance of tissue integrity and is essential for the development of various organs, including the nervous system and the heart. Its functions have been studied extensively in cancer research, as dysregulation of Erbin expression has been shown to contribute to tumorigenesis and metastasis.
Source	Rabbit
Specificity	The detection ability of Erbin Antibody is focused on identifying the existing levels of total Erbin in the system. This antibody is capable of detecting endogenous forms of Erbin.
Species Reactivity	Human;Monkey
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	Erbin
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human Erbin.
MW	158 kDa
Properties
Concentration	1mg/ml
purification	Utilizing SulfoLink™ Coupling Resin, the antiserum was refined through peptide affinity chromatography. This process resulted in a purified product that meets quality standards.
Clonality	Polyclonal Antibody
Stability & Storage	-20°C。/。，。
Storage buffer	This product is Rabbit IgG, which is maintained in a solution of phosphate buffered saline with a pH of 7.4. It contains 150mM NaCl, 0.02% sodium azide, and 50% glycerol for stability. The recommended storage temperature is -20 °C, and it is guaranteed to be stable for a period of 12 months from the date of receipt.
Target
Background	Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and proinflammatory cytokine secretion (PubMed:16203728).
Tissue specificity	Highly expressed in brain, heart, kidney, muscle and stomach, followed by liver, spleen and intestine.
Celluar localization	Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	Q96RT1