Home - Products - Antibodies - Primary Antibodies - Polyclonal Antibody - Details

Rabbit Anti-CYP3A5 Polyclonal Antibody#abs137509

Please note that the price provided is for reference only, and for detailed pricing, please get in touch with our sales representative Vecent. We would like to emphasize that the information shared above should only be used for reference purposes. For accurate pricing details, we recommend...

Send Inquiry

Description

Catalog-specification	Delivery time	USD price
abs137509-100ug	1-2 Weeks	301.0
abs137509-50ug	1-2 Weeks	201.0

Overview
catalog	abs137509
Other names	Flavoprotein linked monooxygenase, also known as Aryl hydrocarbon hydroxylase or Niphedipine oxidase, is an important enzyme belonging to the Cytochrome P450 family. It is encoded by the CP3A5_HUMAN gene and is commonly referred to as CYP3A5 or CYPIIIA5. This cytochrome P450 enzyme plays a significant role in drug metabolism and xenobiotic biotransformation within the human body. It is involved in the oxidation of a wide range of endogenous and exogenous compounds, making it crucial for the clearance and detoxification of various substances. The enzyme is primarily expressed in the liver but can also be found in other tissues. Its functional importance is highlighted by its involvement in the metabolism of numerous medications, including some anti-cancer drugs, immunosuppressants, and several cardiovascular agents. Understanding the structure, function, and expression of CYP3A5 is essential for predicting drug-drug interactions and individualizing drug therapy for patients.
Source	Rabbit
Specificity	Endogenous levels of total CYP3A5 can be effectively identified using the CYP3A5 antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	CYP3A5
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CYP3A5.
MW	57 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we purified the antiserum through peptide affinity chromatography. The process involved selecting the specific peptide sequence that the antiserum targets and then coupling it to the resin. The resin was then used to purify the antiserum, resulting in a highly targeted and effective product. This is a popular method used in the production of purified antibodies for use in research and diagnostics.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of the product, it's recommended to keep it stored at a temperature of -20 °C for up to a year. It's important to avoid exposing it to several rounds of freezing and thawing cycles to prevent any adverse effects on its quality.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline, with a pH of 7.4, 150 millimolar concentration of sodium chloride, 0.02% sodium azide, and 50% glycerol. It is recommended to store the product at -20 degrees Celsius. The solution is stable for a period of 12 months starting from the date of receipt.
Target
Background	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Tissue specificity	P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.
Celluar localization	Endoplasmic reticulum;
UniPort	P20815