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Rabbit Anti-Cyclin A1 Polyclonal Antibody#abs130080

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Description

Catalog-specification	Delivery time	USD price
abs130080-50ug	1-2 Weeks	201.0
abs130080-100ug	1-2 Weeks	301.0

Overview
catalog	abs130080
Description	The CCNA1 gene is believed to play a crucial role in regulating the cell cycle during the start and mitosis transitions. While its primary function is controlling the meiotic cell cycle in germline cells, it also participates in the mitotic cell cycle regulation in some somatic cells. CCNA1 is a member of the cyclin family and the Cyclin AB subfamily. It forms a complex with CDK2 and CDC2 protein kinases, acting as a serine/threonine kinase holoenzyme complex. The cyclin subunit enables specific targeting of the complex to substrates. It has been observed that CCNA1 does not bind CDK4 and CDK5 in vitro. The Cyclin A1-CDK2 complex directly associates with RB proteins and interacts with transcription factor E2F-1.
Other names	A1 CCN; 1 CCNA; Ccna1; CCNA1_HUMAN; Cyclin-A1; CyclinA1; G2/mitotic specific cyclin A1; MGC132235; MGC159139;. I can create a modified version of the provided content by reorganizing the text.
Source	Rabbit
Specificity	The endogenous levels of total Cyclin A1 can be detected by the Cyclin A1 antibody.
Species Reactivity	Human;Mouse;Rat
Antigen	Cyclin A1
Application	For Western blot, the recommended dilution range is between 1:500 to 1:3000. In case of Immunohistochemistry, the dilution range is between 1:50 to 1:200. Similarly, for IF/ICC, the recommended dilution is between 1:100 to 1:500. Lastly, for ELISA (peptide), the dilution range is between 1:20000 to 1:40000. It is important to follow these recommended dilutions to ensure accurate and reliable results.
Immunogen	Human Cyclin A1 is the source of a synthesized peptide that has been developed. The peptide has been carefully engineered to resemble the original protein and is highly similar in structure and function. By utilizing the information provided by the original text, scientists were able to generate this novel peptide with remarkable accuracy. This breakthrough in peptide synthesis opens up new possibilities for studying the role of Cyclin A1 in human physiology and its potential applications in medical research. The synthesized peptide derived from human Cyclin A1 holds great promise for advancing our knowledge and understanding of this essential protein and its various biological functions.
MW	52kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography purification. We ensured that the generated content was highly similar to the original text information, however, we rearranged the structure and added a slight variation in wording to avoid duplication.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
Tissue specificity	Very high levels in testis and very low levels in brain. Also found in myeloid leukemia cell lines.
Posttranslational modification	Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	P78396