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Rabbit Anti-Integrin Alpha4 Polyclonal Antibody#abs131713

Description

Catalog-specification	Delivery time	USD price
abs131713-100ug	1-2 Weeks	301.0
abs131713-50ug	1-2 Weeks	201.0

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Overview
catalog	abs131713
Description	Fibronectin receptors known as integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 play a crucial role in binding to fibronectin. Specifically, they have the ability to recognize and interact with various domains present in the alternatively spliced CS-1 and CS-5 regions of fibronectin. These integrins also serve as receptors for VCAM1, wherein the integrin alpha-4/beta-1 recognizes a specific sequence, namely Q-I-D-S, within the VCAM1 molecule. It is noteworthy that their interaction and recognition mechanisms play a significant role in various biological processes.
Other names	Alpha 4 subunit of the VLA 4 receptor, also known as CD49D, is a member of the CD49 antigen-like family. This molecule plays a crucial role in various cellular functions, including adhesion, migration, and differentiation. It interacts with other integrins and extracellular matrix proteins to regulate cell adhesion and signaling. The ITGA4 gene encodes this molecule, which is expressed on leukocytes, including T cells, B cells, and monocytes. The VLA-4 subunit alpha is a component of the very late activation protein 4 receptor and is essential for immune responses. This receptor is involved in the development of autoimmune diseases, making it an important target for therapeutic intervention. MGC90518 is an alternative name for the ITGA4 gene. Overall, the alpha 4 subunit of the VLA 4 receptor is a critical regulator of immune cell function and an attractive target for therapeutic intervention in immune-related diseases.
Source	Rabbit
Specificity	Endogenous levels of total Integrin alpha4 can be detected by using Integrin alpha4 Antibody. This antibody has been developed to recognize the full length form of Integrin alpha4, and it can be used for a variety of applications including western blotting, immunofluorescence and immunohistochemistry. With its high specificity and sensitivity, Integrin alpha4 Antibody is an essential tool for researchers working in the field of integrin signaling and cell adhesion. Whether you are studying the role of Integrin alpha4 in tumor metastasis or in immune cell trafficking, this antibody is the perfect tool for detecting endogenous levels of this important integrin.
Species Reactivity	Human;Mouse
Predictive reaction species	Bovine;Pig;Sheep
Antigen	Integrin alpha4
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	Integrin alpha4，。，。
MW	115kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly refined end product was achieved through this process.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877).
Posttranslational modification	Phosphorylation on Ser-1027 inhibits PXN binding.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P13612

Western blot analysis of Integrin alpha4 expression in PMA treated Jurkat whole cell lysates,The lane on the left is treated with the antigen-specific peptide.

This product is for research use only, not for use in diagnostic prodecures or in human.

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