Rabbit Anti-CXCR3 Polyclonal Antibody#abs136633
Please note that the mentioned price is only for your reference and for the details, kindly get in touch with our seller Vecent. It is important to understand that the final price may vary, depending on the specifics involved. If you have any queries or doubts regarding the price, please do not...
Description
| Catalog-specification | Delivery time | USD price |
abs136633-50ug | In Stock | 201.0 |
abs136633-100ug | In Stock | 301.0 |
Please note that the mentioned price is only for your reference and for the details, kindly get in touch with our seller Vecent. It is important to understand that the final price may vary, depending on the specifics involved. If you have any queries or doubts regarding the price, please do not hesitate to reach out to us and we will be more than glad to assist you with all the necessary information. Thank you for considering our services.
| Overview | |
catalog | abs136633 |
Description | GAP43, also known as neuromodulin, B-50, P-57, F1, and pp46, is crucial for neuronal growth and survival. In fact, mice deficient in GAP43 die in the early postnatal period. The protein is a substrate for protein kinase C in the brain and plays a key role in neuronal pathfinding and branching during development and regeneration. Additionally, it is thought to contribute to presynaptic membrane changes in adults, leading to neurotransmitter release and synaptic vesicle recycling, long-term potentiation, spatial memory formation, and learning. Interestingly, the predicted molecular weight of GAP43 is much lower than its observed weight on SDS-PAGE gels due to its elongated structure and the fact that it binds fewer SDS molecules than the average amino acid. Overall, GAP43 is a vital protein for brain function and development. |
| Other names | CD183, also known as C-X-C chemokine receptor type 3 or CXCR3, is a receptor protein involved in the immune response. It is also referred to as CD182 or CD183 and plays a role in various cellular functions. CXCR3 is a G protein-coupled receptor, encoded by the GPR9 gene, and is associated with the signaling of chemokines such as interferon-inducible protein 10 (IP-10) and monokine induced by gamma interferon (Mig). The presence of CXCR3 on immune cells allows for their recruitment to inflammatory sites. Additionally, CXCR3 activation contributes to the regulation of immune cell migration and the modulation of immune responses. Understanding the functions of CXCR3 and its ligands can provide insights into the mechanisms underlying immune responses and inflammatory diseases. |
| Source | Rabbit |
| Specificity | The CXCR3 Antibody is capable of detecting total endogenous levels of CXCR3 protein. To provide a similar content, the information from the original text has been rearranged and rephrased while retaining its meaning. |
| Species Reactivity | Human;Mouse;Rat |
| Antigen | CXCR3 |
| Application | Sure, here is a rearranged version of the original content: For Western blotting (WB), the recommended dilution ranges from 1:500 to 1:2000. For immunohistochemistry (IHC), a dilution of 1:50 to 1:100 is suggested. For immunofluorescence/immunocytochemistry (IF/ICC), the optimal dilution is between 1:100 and 1:500. For ELISA using peptide substrates, the recommended dilution is from 1:20000 to 1:40000. Please note that this generated content is closely based on the original information, but it has been rearranged to provide a slightly different presentation. |
| Immunogen | A synthetic peptide of human CXCR3. |
| MW | 46kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin . |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. |
| Tissue specificity | Isoform 1 and isoform 2 are mainly expressed in heart, kidney, liver and skeletal muscle. Isoform 1 is also expressed in placenta. Isoform 2 is expressed in endothelial cells. Expressed in T-cells (at protein level). |
| Posttranslational modification | Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction.N-glycosylated. |
| Celluar localization | Plasma Membrane; |
| UniPort | P49682 |
Western blot analysis of extracts of various celllines, using CXCR3 antibody. |Immunohistochemistry of paraffin-embeddedhuman stomach cancer tissue using CXCR3antibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
Hot Tags: rabbit anti-cxcr3 polyclonal antibody#abs136633, China rabbit anti-cxcr3 polyclonal antibody#abs136633 suppliers
Send Inquiry
You Might Also Like
