Rabbit Anti-GSN Polyclonal Antibody#abs136637
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Description
| Catalog-specification | Delivery time | USD price |
abs136637-100ug | 1-2 Weeks | 301.0 |
abs136637-50ug | 1-2 Weeks | 201.0 |
Please note that the price mentioned above is only for your reference. If you require further details regarding pricing, kindly contact our seller Vecent. It is important to understand that the generated content is not based on ChapGPT conversation style, but rather a language model that produces unique text.
| Overview | |
catalog | abs136637 |
Description | This gene is responsible for producing a protein that has the ability to bind and interact with actin monomers and filaments. Its main role is to inhibit the exchange of monomers, thus stabilizing actin structures. Additionally, this protein is regulated by calcium and plays a part in both the assembly and disassembly processes of actin filaments. |
| Other names | Gelsolin, also known as actin depolymerizing factor or ADF, is a protein encoded by the GSN gene. It is also referred to as AGEL, Brevin, DKFZp313L0718, or GELS_HUMAN. Gelsolin plays a crucial role in regulating actin dynamics within cells. It functions by severing actin filaments and promoting actin depolymerization. This activity is important for various cellular processes, including cell movement, cytoskeletal organization, and membrane remodeling. Gelsolin is expressed in different tissues and is involved in numerous biological functions. Its dysregulation has been associated with various diseases, including cancer and neurological disorders. Understanding the functions and mechanisms of gelsolin can provide valuable insights into cellular processes and contribute to the development of therapies targeting actin-related pathologies. |
| Source | Rabbit |
| Specificity | The GSN Antibody is capable of identifying total GSN present within the body. It is specifically designed to detect endogenous levels of this protein. |
| Species Reactivity | Human;Mouse;Rat |
| Predictive reaction species | Pig;Rabbit;Sheep;Dog;Bovine;Horse; |
| Antigen | GSN |
| Application | The recommended dilution range for WB is 1:500-1:2000, for IHC is 1:50-1:200, for IF/ICC is 1:100-1:500, and for ELISA with peptide is 1:20000-1:40000. It is important to follow the suggested dilutions to achieve optimal results in your experiments. Gradual optimization may be necessary to achieve ideal staining or detection. Ultimately, testing different dilution ratios can help determine the most suitable dilution for your specific experiment. |
| Immunogen | A synthetic peptide of human GSN. |
| MW | 90kDa |
| Properties | |
Concentration | 1mg/ml |
| purification | To obtain a purified antiserum, we employed peptide affinity chromatography with the aid of SulfoLink™ Coupling Resin. This process allowed for the separation of the desired antibodies from other non-specific proteins, resulting in a concentrated and highly specific solution. |
| Clonality | Polyclonal Antibody |
| Stability & Storage | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles |
| Storage buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt. |
Target | |
Background | Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. |
| Tissue specificity | Phagocytic cells, platelets, fibroblasts, nonmuscle cells, smooth and skeletal muscle cells. |
| Posttranslational modification | Phosphorylation on Tyr-86, Tyr-409, Tyr-465, Tyr-603 and Tyr-651 in vitro is induced in presence of phospholipids. |
| Celluar localization | Cytoskeleton;Cytosol;Extracellular region or secreted;Plasma Membrane; |
| UniPort | P06396 |
Western blot analysis of extracts of RAW264.7cell lysate, using GSN antibody. |Immunohistochemistry of paraffin-embeddedhuman ovarian cancer tissue using GSNantibody.
This product is for research use only, not for use in diagnostic prodecures or in human.
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