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Rabbit Anti-CPT1B Polyclonal Antibody#abs140983

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Description

Catalog-specification	Delivery time	USD price
abs140983-100ug	1-2 Weeks	301.0
abs140983-50ug	1-2 Weeks	201.0

Overview
catalog	abs140983
Other names	Carnitine O-palmitoyltransferase 1B, also known as CPT1B, is an enzyme that plays a crucial role in muscle metabolism. It belongs to the carnitine palmitoyltransferase family and is specifically expressed in muscle tissues. CPT1B is responsible for the transportation of long-chain fatty acids into the mitochondria, where they are oxidized for energy production. The muscle isoform of CPT1B, also referred to as CPT1-M, is highly similar to the other isoforms found in different tissues. However, the muscle isoform is specifically tailored to meet the energy demands of muscle cells. It exhibits a higher affinity for long-chain fatty acids, allowing for efficient transport and subsequent oxidation. CPT1B is encoded by the CPT1B gene and is essential for maintaining proper muscle function. Mutations in the CPT1B gene have been associated with metabolic disorders, such as carnitine palmitoyltransferase 1 deficiency, which can result in muscle weakness, fatigue, and other symptoms. In summary, CPT1B is a crucial enzyme involved in muscle metabolism, particularly in the transport and oxidation of long-chain fatty acids. Its muscle isoform, CPT1-M, is specialized for the energy needs of muscle cells. Understanding the function of CPT1B can provide insights into muscle-related disorders and potentially lead to the development of targeted therapies.
Source	Rabbit
Specificity	Endogenous levels of total CPT1B can be detected using the CPT1B Antibody.
Species Reactivity	Human
Antigen	CPT1B
Application	For Western blotting, the recommended dilution range is between 1:500 to 1:1000. For immunohistochemistry, the optimal dilution range is between 1:50 to 1:200. When using this antibody for immunofluorescence or immunocytochemistry, it is suggested to use a dilution range of 1:100 to 1:500. For ELISA detection using peptide, the dilution recommended is between 1:20000 to 1:40000. It is important to follow the recommended dilution range to ensure accurate and reliable results in your experiments.
Immunogen	A synthesized peptide.
MW	88 KD
Properties
Concentration	1mg/ml
purification	By utilizing SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar statement can be created by rearranging the original text, making sure to convey the same information in a slightly different way.
Clonality	Polyclonal Antibody
Stability & Storage	Please ensure that the product is stored at -20 °C for a period of one year in order to maintain its efficacy. It is important to avoid subjecting the product to repeated freeze/thaw cycles as this can affect its quality.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	This protein is produced by a bicistronic gene which also produces the CHKB protein from a non-overlapping reading frame.
Tissue specificity	Strong expression in heart and skeletal muscle. No expression in liver and kidney.
Celluar localization	Mitochondrion;
UniPort	Q92523