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Rabbit Anti-COMT Polyclonal Antibody#abs140984

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Description

Catalog-specification	Delivery time	USD price
abs140984-100ug	1-2 Weeks	301.0
abs140984-50ug	1-2 Weeks	201.0

Overview
catalog	abs140984
Other names	COMT, also known as Catechol O-methyltransferase, is an enzyme that plays an important role in the metabolism of catecholamines. This enzyme is encoded by the COMT_HUMAN gene and has the EC number 2.1.1.6. Its main function is to catalyze the transfer of a methyl group from S-adenosylmethionine to the hydroxyl group of catecholamines such as dopamine, epinephrine, and norepinephrine. This process is essential for the breakdown of these neurotransmitters and the regulation of their levels in the body. Dysregulation of COMT activity has been linked to various psychiatric and neurological disorders, including Parkinson's disease and schizophrenia. Therefore, understanding the function and regulation of COMT is of great importance in the field of neuroscience and drug development.
Source	Rabbit
Specificity	Total COMT can be detected by utilizing the COMT Antibody, which has the ability to recognize endogenous levels of this enzyme. To emphasize the importance of maintaining the original text information, please note that the generated content should be highly similar but rearranged in structure.
Species Reactivity	Human;Mouse
Antigen	COMT
Application	The recommended dilution range for Western Blot (WB) is 1:500 to 1:1000. For Immunofluorescence (IF)/Immunocytochemistry (ICC), the suggested dilution range is 1:100 to 1:500. In the case of ELISA using a peptide, the suitable dilution range is 1:20000 to 1:40000. It is important to note that these dilution ranges are based on the original information provided.
Immunogen	A synthesized peptide.
MW	30 KD
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to avoid exposing the product to repeated cycles of freezing and thawing, as this can potentially damage its properties. Therefore, it is crucial to take appropriate measures in maintaining the product's temperature to ensure its longevity and effectiveness.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline with a pH of 7.4 and 150mM NaCl, supplemented with 0.02% sodium azide and 50% glycerol. It is recommended to store this product at a temperature of -20°C for optimal conservation and stability, where it can remain viable for a period of up to 12 months from the date of receipt.
Target
Background	This enzyme plays a crucial role in deactivating catecholamine neurotransmitters and catechol hormones by catalyzing the process of O-methylation. It also effectively reduces the half-lives of certain neuroactive drugs, such as L-DOPA, alpha-methyl DOPA, and isoproterenol. Its ability to shorten the biological half-lives of these drugs makes it an essential enzyme in pharmacology and biochemistry studies.
Tissue specificity	Brain, liver, placenta, lymphocytes and erythrocytes.
Posttranslational modification	The N-terminus is blocked.
Celluar localization	Cytosol;Extracellular region or secreted;Mitochondrion;Plasma Membrane;
UniPort	P21964