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Rabbit Anti-DFFA Polyclonal Antibody#abs137424

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Description

Catalog-specification	Delivery time	USD price
abs137424-100ug	1-2 Weeks	301.0
abs137424-50ug	1-2 Weeks	201.0

Overview
catalog	abs137424
Other names	The A330085O09Rik gene is known by several names, including DFFA, ICAD, and H13. It encodes a protein called DNA fragmentation factor alpha subunit (DFFA), which is involved in the fragmentation of DNA during programmed cell death. DFFA is also an inhibitor of Caspase Activated DNase (CAD), which protects DNA from excessive fragmentation. Additionally, it has two isoforms, ICAD L and ICAD S, which regulate DFFA's activity. DFFA is crucial for proper cell death and its dysfunction has been linked to various diseases.
Source	Rabbit
Specificity	The DFFA Antibody is designed to recognize and bind to the total amount of endogenous DFFA present in a biological sample. By targeting this specific protein, researchers can gain insights into various cellular processes and signaling pathways. The antibody is highly selective and reliable, making it an ideal tool for both basic research and clinical applications.
Species Reactivity	Human
Antigen	DFFA
Application	WB 1:1000-3000，IF/ICC 1:100-1:500，ELISA（）1:20000-1:40000。，。
Immunogen	A synthesized peptide derived from human DFFA.
MW	37 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was used to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Inhibitor of the caspase-activated DNase (DFF40).
Posttranslational modification	Caspase-3 cleaves DFF45 at 2 sites to generate an active factor.
Celluar localization	Cytosol;Nucleus;Plasma Membrane;
UniPort	O00273