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Rabbit Anti-CPB2 Polyclonal Antibody#abs140976

Description

Catalog-specification	Delivery time	USD price
abs140976-100ug	1-2 Weeks	301.0
abs140976-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140976
Other names	Carboxypeptidase B-like protein, also known as plasma carboxypeptidase B and plasma carboxypeptidase B2, is a well-known carboxypeptidase found in mammals. It is encoded by various genes, including 1110032P04Rik, 4930405E17Rik, bA139H14.2, Carboxypeptidase B2, and Carboxypeptidase U (CPU), among others. Procarboxypeptidase B, Procarboxypeptidase R, and Procarboxypeptidase U are precursors to carboxypeptidase B2 and thrombin activatable fibrinolysis inhibitor (TAFI). CPB2 and CPU are both involved in regulating various biological processes, including the fibrinolytic system and blood clotting. Thrombin activatable fibrinolysis inhibitor (TAFI) is a plasma protein that is activated by thrombin and functions as an inhibitor of fibrinolysis. It is also known as carboxypeptidase U (CPU) due to its ability to remove C-terminal lysine and arginine residues from peptides and proteins. In conclusion, these carboxypeptidases and inhibitors are important for maintaining proper coagulation and fibrinolysis in the body, and further research is needed to fully understand their roles and potential therapeutic applications.
Source	Rabbit
Specificity	The CPB2 Antibody has the ability to detect total CPB2 levels that are present in the body naturally. The antibody is designed to specifically target the CPB2 protein, allowing for accurate and reliable measurements of its presence. With this antibody, researchers can gain insights into the role of CPB2 in various physiological processes, including blood coagulation and fibrinolysis. Overall, this antibody serves as a valuable tool for studying the function and regulation of CPB2 in the body.
Species Reactivity	Human
Predictive reaction species	Rabbit
Antigen	CPB2
Application	To ensure optimal results, it is recommended to use a dilution ratio of 1:500~1:1000 for Western blotting, and 1:100-1:500 for immunofluorescence/immunocytochemistry experiments. For ELISA using peptide, a dilution ratio of 1:20000-1:40000 is suggested. Following these guidelines can lead to accurate and reliable data in your experiments.
Immunogen	A synthesized peptide.
MW	48 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality and freshness, it is highly recommended to store the item at a temperature of -20 °C for a duration of one year. It is crucial to avoid any form of repeated freezing or thawing cycles to maintain the integrity of the product.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin.
Tissue specificity	Plasma; synthesized in the liver.
Posttranslational modification	N-glycosylated. N-glycan at Asn-108: Hex5HexNAc4.
Celluar localization	Extracellular region or secreted;
UniPort	Q96IY4