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Rabbit Anti-COX7A1 Polyclonal Antibody#abs139618

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Description

Catalog-specification	Delivery time	USD price
abs139618-100ug	1-2 Weeks	301.0
abs139618-50ug	1-2 Weeks	201.0

Overview
catalog	abs139618
Other names	Cytochrome c oxidase subunit 7A1, also known as COX7A, COX7A1, COX7AH, COX7AM, CX7A1_HUMAN, and mitochondrial cytochrome c oxidase subunit VIIa, is an important polypeptide that plays a crucial role in energy production within the cell. This protein is found in the mitochondria of cells and is involved in the regulation of oxidative phosphorylation, the process by which cells generate ATP, the main source of energy for the body. COX7A1 is expressed in various tissues, including heart and muscle tissues. It has been found to have multiple isoforms, such as the heart/muscle isoform, which is responsible for maintaining the proper function of mitochondria in these tissues. Additionally, COX7A1 is also found in other tissues, such as the liver and brain, and has been linked to several metabolic disorders, including diabetes, obesity, and Alzheimer's disease. Downregulation of COX7A1 has been associated with decreased activity of the respiratory chain complex IV and has been implicated in the pathogenesis of various diseases. Mutations in COX7A1 can cause mitochondrial disorders, which typically present with impaired oxidative phosphorylation and increased generation of reactive oxygen species. Finally, COX7A1 has been suggested as a potential therapeutic target for the treatment of metabolic disorders and neurodegenerative diseases.
Source	Rabbit
Specificity	The COX7A1 Antibody is capable of detecting total COX7A1 levels that are present in the body naturally. This means that the antibody is able to recognize and bind to COX7A1 molecules that are already in the system without the need for any external stimuli.
Species Reactivity	Human
Antigen	COX7A1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human COX7A1.
MW	9 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography method. Reordering the original information is requested to generate highly similar content.
Clonality	Polyclonal Antibody
Stability & Storage	Please ensure that the product is stored at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting it to repetitive freezing and thawing cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.
Celluar localization	Mitochondrion;
UniPort	P24310