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Rabbit Anti-CITED1 Polyclonal Antibody#abs137380

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Description

Catalog-specification	Delivery time	USD price
abs137380-100ug	1-2 Weeks	301.0
abs137380-50ug	1-2 Weeks	201.0

Overview
catalog	abs137380
Other names	Cited1 is a gene also known as ABCC1, AI316840, AU019144, or Cbp/p300-interacting transactivator 1. It is a transactivator protein that interacts with Cbp/p300 and has a Glu/Asp-rich C-terminal domain. Cited1 is also referred to as Cbp/p300-interacting transactivator with GLU/ASP-rich C-terminal domain 1 or Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1. Additionally, it is sometimes called melanocyte-specific gene 1 or Melanocyte-specific protein 1. Cited1 plays a role in melanocyte development and is commonly abbreviated as MSG1.
Source	Rabbit
Specificity	The CITED1 antibody is capable of detecting total endogenous levels of CITED1 protein. This means that it can accurately identify and measure the protein levels contained within a sample. It is important to use a reliable and effective antibody for protein detection in order to obtain accurate results in experiments and studies.
Species Reactivity	Human
Antigen	CITED1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CITED1.
MW	20 kDa
Properties
Concentration	1mg/ml
purification	Through the utilization of SulfoLink™ Coupling Resin, the antiserum was effectively purified by means of peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the quality of the product, it is recommended to store it at -20 °C for a period of one year. It is important to avoid exposing the product to repeated freeze and thaw cycles, as this can compromise its integrity and effectiveness. Therefore, it is advisable to handle the product with care and follow the storage guidelines to ensure its optimal performance.
Storage buffer	Store at -20 °C, Rabbit IgG in phosphate buffered saline at pH 7.4 with 150 mM NaCl, 0.02% sodium azide, and 50% glycerol. It remains stable for 12 months from the date of receipt.
Target
Background	Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.
Tissue specificity	Expressed only in melanocytes and testis.
Posttranslational modification	Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.
Celluar localization	Cytosol;Nucleus;
UniPort	Q99966