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Rabbit Anti-CFP Polyclonal Antibody#abs136832

Description

Catalog-specification	Delivery time	USD price
abs136832-100ug	1-2 Weeks	301.0
abs136832-50ug	1-2 Weeks	201.0

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Overview
catalog	abs136832
Description	This particular gene is responsible for producing a glycoprotein found in plasma that plays a crucial role in the alternative pathway of the innate immune system. Its purpose is to regulate the pathway in a positive manner. When this protein binds to the surface of various microbes or apoptotic cells, it stabilizes the enzyme complexes C3 and C5 in a feedback loop fashion. This eventually results in the formation of the membrane attack complex, which then leads to the destruction of the targeted cell. Unfortunately, if there are any mutations present in this gene, it can result in two different types of properdin deficiency. This condition makes individuals highly susceptible to meningococcal infections. There are multiple spliced variants of the same protein, yet all of them perform the same function.
Other names	Properdin, also known as complement factor P or factor properdin, is a key protein involved in the complement system. It is encoded by the CFP gene and helps to activate the alternative pathway of the complement system, which is essential for fighting infections and removing damaged cells from the body. Properdin is a glycoprotein that circulates in the bloodstream and is produced by various immune cells. When activated, it binds to the C3b protein, which triggers a cascade of events that result in the formation of the membrane attack complex (MAC) and the destruction of the target cell. Deficiencies in properdin have been linked to increased susceptibility to bacterial infections, particularly Neisseria meningitidis, which can cause meningitis and sepsis. In addition, mutations in the CFP gene have been associated with atypical hemolytic uremic syndrome (aHUS), a rare disorder of the blood vessels that can lead to acute kidney failure and other complications. Overall, properdin plays a critical role in the immune response and maintaining the integrity of the complement system. Its functions are complex and multifaceted, and ongoing research is needed to fully understand its mechanisms of action and potential therapeutic applications.
Source	Rabbit
Specificity	The CFP Antibody is capable of detecting total CFP levels that occur naturally within the body. This means that it can accurately detect the presence and quantity of this protein without any interference from external factors. This information is crucially important for studying various biological processes and can be utilized to understand the role of CFP in various diseases and conditions. By analyzing CFP levels in different tissues and under different conditions, researchers can gain insight into the mechanisms involved in various biological processes, leading to the development of new treatments and therapies.
Species Reactivity	Human;Mouse;Rat
Antigen	CFP
Application	The dilutions recommended for Western blot (WB) range from 1:500 to 1:2000, for immunohistochemistry (IHC) from 1:50 to 1:200, and for ELISA using a peptide antigen from 1:20000 to 1:40000. Please note that the generated content is based on the original text information.
Immunogen	A synthesized peptide derived from human CFP.
MW	51kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. A highly comparable content can be generated by rearranging the words, which still retains the original information of the text.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.
Celluar localization	Endoplasmic reticulum;Extracellular region or secreted;
UniPort	P27918