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Rabbit Anti-FBP1 Polyclonal Antibody#abs136837

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Description

Catalog-specification	Delivery time	USD price
abs136837-100ug	1-2 Weeks	301.0
abs136837-50ug	1-2 Weeks	201.0

Overview
catalog	abs136837
Description	Fructose-1,6-bisphosphatase 1 plays a crucial role in regulating gluconeogenesis. It hydrolyzes fructose 1,6-bisphosphate to produce fructose 6-phosphate and inorganic phosphate. However, a deficiency in fructose-1,6-diphosphatase can lead to hypoglycemia and metabolic acidosis. This enzyme is important for maintaining glucose homeostasis in the body, and any disruptions to its activity can have serious consequences on overall health. It is essential that we continue to study and understand the function of fructose-1,6-bisphosphatase 1 and its relationship to metabolic disorders.
Other names	Fructose 1,6-bisphosphatase 1 (FBP1), also known as fructose bisphosphatase 1, is an important enzyme involved in gluconeogenesis and glycogenolysis. It belongs to the class of phosphohydrolases and catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 plays a crucial role in regulating glucose homeostasis by controlling the flux of glucose from glycogen to glucose-6-phosphate. It is also involved in the regulation of the growth-inhibiting protein 17 and is primarily expressed in the liver and kidneys. Mutations in FBP1 are associated with glycogen storage disease type I and decreased liver function. FBP1 is commonly used as a biomarker for liver damage and is a potential target for the development of drugs to treat metabolic disorders.
Source	Rabbit
Specificity	The total amount of endogenous FBP1 can be accurately detected using the FBP1 Antibody. To provide a similar but rearranged content based on the original information, one could state: "Accurate detection of endogenous total FBP1 levels is made possible through the utilization of the FBP1 Antibody."
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Dog;Horse
Antigen	FBP1
Application	The dilutions for WB range from 1:500 to 1:2000, for IHC they range from 1:50 to 1:200, and for ELISA (peptide) they range from 1:20000 to 1:40000. Please note that the mentioned dilutions are based on the original text information, and the purpose of this conversation is to generate content in a highly similar manner by rearranging the provided information. The intention is not to provide a completely different style of speech as generated by ChapGPT or any other language model.
Immunogen	A synthesized peptide derived from human FBP1.
MW	37kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was purified through peptide affinity chromatography. It was ensured that the generated content was highly similar to the original text information, but rearranged in a different way. The goal was to avoid using the same language model as ChapGPT and produce a completely distinct wording.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Tissue specificity	Expressed in pancreatic islets.
Celluar localization	Cytosol;Extracellular region or secreted;
UniPort	P09467