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Rabbit Anti-CDK6 Polyclonal Antibody#abs135968

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Description

Catalog-specification	Delivery time	USD price
abs135968-100ug	1-2 Weeks	301.0
abs135968-50ug	1-2 Weeks	201.0

Please note that the price provided above is for your reference only. For detailed pricing information, kindly get in touch with our seller Vecent.
We kindly request you to contact Vecent, our seller, for precise pricing details as the mentioned price is intended for your reference only.

Overview
catalog	abs135968
Other names	Human CDK6, also known as Cyclin Dependent Kinase 6 or Cell Division Protein Kinase 6, plays a crucial role in cell division and proliferation. It is encoded by the CDK6 gene and also referred to as CDK6_HUMAN. Other aliases include Crk2, MCPH12, p40, PLSTIRE, and STQTL11. This serine/threonine protein kinase is involved in regulating the cell cycle by phosphorylating target proteins. CDK6 forms complexes with cyclin D and acts as a key regulator in the G1 phase of the cell cycle. It is highly similar to Crk2 and MGC59692, which are alternative names for this protein. Understanding the function and regulation of CDK6 is essential in uncovering its potential role in various cellular processes and diseases.
Source	Rabbit
Specificity	The ability of CDK6 Antibody to identify total CDK6 present in the body's natural levels has been demonstrated. To elaborate, the antibody specifically recognizes endogenous CDK6. Instead of following a question-and-answer format, I will present the information in a more unique manner using the language model.
Species Reactivity	Human;Mouse;Rat
Antigen	CDK6
Application	The dilution ranges for WB, IHC, and ELISA (peptide) are as follows: WB 1:500-1:2000, IHC 1:50-1:200, and ELISA(peptide) 1:20000-1:40000. Please rearrange the provided information to generate similar content.
Immunogen	A synthesized peptide derived from human CDK6.
MW	36kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized for peptide affinity chromatography to purify the antiserum. Please create a new piece of content by reorganizing the provided information while maintaining its original context.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freezing and thawing cycles, as this could negatively impact its efficacy and overall performance. Please ensure that the product is stored appropriately to maintain its integrity and efficacy over time.
Storage buffer	The storage condition for Rabbit IgG is in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C. The Rabbit IgG is stable for a period of 12 months from the date of receipt.
Target
Background	Serine/threonine-protein kinase involved in the control of the cell cycle and differentiation; promotes G1/S transition. Phosphorylates pRB/RB1 and NPM1. Interacts with D-type G1 cyclins during interphase at G1 to form a pRB/RB1 kinase and controls the entrance into the cell cycle. Involved in initiation and maintenance of cell cycle exit during cell differentiation; prevents cell proliferation and regulates negatively cell differentiation, but is required for the proliferation of specific cell types (e.g. erythroid and hematopoietic cells). Essential for cell proliferation within the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricles. Required during thymocyte development. Promotes the production of newborn neurons, probably by modulating G1 length. Promotes, at least in astrocytes, changes in patterns of gene expression, changes in the actin cytoskeleton including loss of stress fibers, and enhanced motility during cell differentiation. Prevents myeloid differentiation by interfering with RUNX1 and reducing its transcription transactivation activity, but promotes proliferation of normal myeloid progenitors. Delays senescence. Promotes the proliferation of beta-cells in pancreatic islets of Langerhans. May play a role in the centrosome organization during the cell cycle phases (PubMed:23918663).
Tissue specificity	Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells.
Posttranslational modification	Thr-177 phosphorylation and Tyr-24 dephosphorylation promotes kinase activity.
Celluar localization	Cytoskeleton;Cytosol;Nucleus;
UniPort	Q00534