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Rabbit Anti-UBQLN2 Polyclonal Antibody#abs139500

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Description

Catalog-specification	Delivery time	USD price
abs139500-100ug	1-2 Weeks	301.0
abs139500-50ug	1-2 Weeks	201.0

Overview
catalog	abs139500
Other names	There is a protein that goes by many names including bA431N15.1, CHAP 1, CHAP1, CHAP1/DSK2, Dsk 2, Dsk2, DSK2 homolog, hPLIC 2, hPLIC2, HRIHFB2157, LIC 2, LIC2, N4BP4, Nedd4 binding protein 4, PLIC 2, PLIC2, Protein linking IAP with cytoskeleton 2, RIHFB2157, Ubiquilin 2, Ubiquilin2, Ubiquitin like product Chap1/Dsk2, and UBQLN 2. This protein plays an important role in the body's cellular processes, specifically in the regulation of protein degradation and removal of damaged or misfolded proteins. It is also involved in the immune response and has been linked to various diseases such as Alzheimer's and cancer. Despite its many names, the function and importance of this protein remains significant in the study of human health and disease.
Source	Rabbit
Specificity	The detection of total UBQLN2 at endogenous levels can be achieved using the UBQLN2 Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Pig;Dog;
Antigen	UBQLN2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human UBQLN2.
MW	66 kDa
Properties
Concentration	1mg/ml
purification	We utilized SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain optimal storage conditions, it is recommended to store at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles during this storage period.
Storage buffer	The Rabbit IgG comes in a solution of phosphate buffered saline at pH 7.4, with 150mM NaCl, 0.02% sodium azide, and 50% glycerol, and must be stored at -20 °C. It is stable for a year from the date of receipt.
Target
Background	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:19148225, PubMed:20529957). Negatively regulates the endocytosis of GPCR receptors: AVPR2 and ADRB2, by specifically reducing the rate at which receptor-arrestin complexes concentrate in clathrin-coated pits (CCPs) (PubMed:18199683).
Tissue specificity	Highly expressed in mitotic cells from metaphase to telophase. Expression in non-mitotic cells is very low.
Posttranslational modification	Degraded during macroautophagy.
Celluar localization	Cytosol;Nucleus;Plasma Membrane;
UniPort	Q9UHD9