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Rabbit Anti-CD71/TfR Polyclonal Antibody#abs131442

Rabbit Anti-CD71/TfR Polyclonal Antibody#abs131442

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Description

Catalog-specificationDelivery timeUSD price

abs131442-100ug

1-2 Weeks

301.0

abs131442-50ug

1-2 Weeks

201.0

Kindly note that the price mentioned above is only for your reference. To obtain the detailed price, kindly get in touch with our competent seller, Vecent. It is important to ensure that the content generated is based on the original text to maintain its authenticity. Therefore, kindly avoid using ChapGPT to generate a similar content style and use a different language model to produce distinct and unique content.


Overview

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abs131442

Description

Negatively regulating telomere length, it binds to the telomeric double-stranded TTAGGG repeat. Furthermore, it plays a role in the regulation of the mitotic spindle. This protein is a crucial component of the shelterin complex, also known as telosome, which is responsible for both the maintenance of telomere length and protection.

Other namesThe CD71 antigen, also known as CD71 or transferrin receptor protein 1, is a crucial protein involved in cellular iron uptake. It is also referred to as IMD46, OTTHUMP00000208523, OTTHUMP00000208524, OTTHUMP00000208525, p90, sTfR, T9, TfR, TfR1, TFR1_HUMAN, TFRC, and TR. The CD71 protein, commonly found as a serum form, plays a vital role in binding and internalizing transferrin, a protein responsible for iron transportation in the body. Its significance lies in maintaining iron homeostasis, as cells require iron for various metabolic processes. By rearranging the above content, we can comprehend the various names and functions associated with CD71, a fundamental component related to iron metabolism.
SourceRabbit
SpecificityThe total CD71/TfR levels can be detected using the CD71/TfR Antibody, which is capable of detecting endogenous CD71/TfR.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesPig;Rabbit;Sheep;Dog;Bovine;Horse;
AntigenCD71/TfR
ApplicationThe recommended dilutions for WB are 1:500-1:2000, for IHC they are 1:50-1:200, and for IF/ICC they are 1:100-1:500. For ELISA using peptide, the suggested dilutions are 1:20000-1:40000. It is important to note that these dilutions are based on the original information provided.
ImmunogenA synthesized peptide derived from human CD71/TfR.
MW49 kDa
Properties

Concentration

1mg/ml

purificationSulfoLink™ Coupling Resin was utilized for peptide affinity chromatography in order to purify the antiserum. This led to the production of a highly purified antiserum that could be used effectively in various research applications.
ClonalityPolyclonal Antibody
Stability & StorageStore at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).

Tissue specificityRegulated by cellular iron levels through binding of the iron regulatory proteins, IRP1 and IRP2, to iron-responsive elements in the 3'-UTR. Up-regulated upon mitogenic stimulation.
Posttranslational modificationN- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.Proteolytically cleaved on Arg-100 to produce the soluble serum form (sTfR).Palmitoylated on both Cys-62 and Cys-67. Cys-62 seems to be the major site of palmitoylation.
Celluar localizationEndosome;Extracellular region or secreted;Plasma Membrane;
UniPortP02786


This product is for research use only, not for use in diagnostic prodecures or in human.


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