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Rabbit Anti-CD130/gp130 Polyclonal Antibody#abs131809

Please keep in mind that the price mentioned above is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent. This product is for research use only, not for use in diagnostic prodecures or in human.

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Description

Catalog-specification	Delivery time	USD price
abs131809-100ug	1-2 Weeks	301.0
abs131809-50ug	1-2 Weeks	201.0

Please keep in mind that the price mentioned above is for your reference only. For detailed pricing information, please get in touch with our seller, Vecent.

Overview
catalog	abs131809
Description	The gene in question encodes a protein that acts as a signal transducer for various cytokines, such as interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This particular protein plays a crucial role in the cytokine receptor complex. Its activation heavily relies on the binding of cytokines to their respective receptors.
Other names	The CD130 antigen, also known as CDw130 or gp130, is a crucial component of the IL-6 receptor. It plays a significant role in transmitting signals from IL-6, a pro-inflammatory cytokine. The IL-6 receptor subunit beta, also referred to as IL-6R subunit beta or IL-6RB, is another name for CD130. It is involved in mediating the effects of IL-6 in various biological processes. Additionally, CD130 is known as the membrane glycoprotein 130 or gp130, and it is associated with the IL-6 signaling pathway. It is also an essential subunit of other cytokine receptors, such as the oncostatin M receptor and the interleukin receptor beta chain. The IL-6 receptor subunit beta, or CD130, can be found in different tissues and cell types. It acts as a signal transducer, relaying signals from IL-6 to initiate cellular responses. It is essential for the activation of the JAK-STAT signaling pathway, which plays a critical role in regulating immune responses and inflammation. Overall, CD130 is a versatile protein involved in various signaling pathways and biological processes. Its presence and functions are essential for proper immune system functioning and response to inflammation.
Source	Rabbit
Specificity	Total CD130/gp130 can be detected in its endogenous levels using the CD130/gp130 Antibody. This antibody is designed to bind to the receptor and identify its presence in biological samples. Through this technique, researchers can study the expression of CD130/gp130 and observe its potential role in various physiological processes. Hence, the antibody provides a useful tool for conducting relevant experiments and furthering our understanding of this protein's function.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	CD130/gp130
Application	。WB（Western blotting）1:500-1:2000，IHC（）1:50-1:200，IF/ICC（/）1:100-1:500，ELISA（，）1:20000-1:40000。，，：，：WB，1:500-1:2000；IHC，1:50-1:200；IF/ICC，1:100-1:500；ELISA，，1:20000-1:40000。，。
Immunogen	A synthetic peptide has been produced that is derived from the human CD130/gp130 protein. This peptide closely resembles the original protein and has been created through careful rearrangement of the original text information. The synthesized peptide may have potential therapeutic applications and could be useful in further studies of the CD130/gp130 protein. It is important to note that this synthetic peptide is not identical to the original protein, but rather a highly similar representation that has been selectively created through scientific methods.
MW	160kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases (PubMed:2261637). That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3 (PubMed:19915009, PubMed:23294003). Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism (By similarity). Has a role in embryonic development (By similarity). Does not bind IL6 (PubMed:2261637). Essential for survival of motor and sensory neurons and for differentiation of astrocytes (By similarity). Required for expression of TRPA1 in nociceptive neurons (By similarity). Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation (By similarity). Required for normal trabecular bone mass and cortical bone composition (By similarity).
Tissue specificity	Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561).
Posttranslational modification	Phosphorylation of Ser-782 down-regulates cell surface expression.Heavily N-glycosylated (PubMed:11098061, PubMed:16335952, PubMed:19159218, PubMed:19139490, PubMed:11251120). Glycosylation is required for protein stability and localization in plasma membrane but not for ligand binding (PubMed:19915009).
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P40189