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Rabbit Anti-CD109 Polyclonal Antibody#abs132688

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Description

Catalog-specification	Delivery time	USD price
abs132688-100ug	1-2 Weeks	301.0
abs132688-50ug	1-2 Weeks	201.0

Overview
catalog	abs132688
Description	In keratinocytes, the signaling of TGFB1 is inhibited by a negative modulation mechanism.
Other names	CD109, also known as TGF-beta-1-binding protein or C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7, is a 150 KDa protein that plays a role in TGF-beta signaling. It is also an activated T cell marker and is involved in platelet-specific Gov antigen. CD109 is encoded by the CD109 gene and is expressed on the cell surface. It has been implicated in various cellular processes and is associated with certain diseases. Additionally, CD109 has been identified as a potential therapeutic target in some cases. Overall, CD109 is a multifunctional protein involved in immune regulation and platelet function.
Source	Rabbit
Specificity	The detection of endogenous total CD109 can be achieved using the CD109 antibody. Reorganizing the original text, we can state that the CD109 antibody is capable of identifying and quantifying the levels of total CD109 present within a biological sample.
Species Reactivity	Human;Mouse
Antigen	CD109
Application	WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide.
MW	162 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum was subjected to peptide affinity chromatography for purification. Please provide a substantially different version of the generated content, ensuring that it is based on the original text information.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure proper storage, it is recommended to keep the item at a temperature of -20 °C for a period of one year. It is important to avoid exposing the sample to repeated cycles of freezing and thawing as this may impact its quality and viability.
Storage buffer	Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Target
Background	Modulates negatively TGFB1 signaling in keratinocytes.
Tissue specificity	Widely expressed with high level in uterus, aorta, heart, lung, trachea, placenta and in fetal heart, kidney, liver, spleen and lung. Expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T-lymphoblasts, endothelial cells and activated platelets. Isoform 4 is expressed in placenta. Isoform 1 is expressed in keratinocytes and placenta.
Posttranslational modification	N-glycosylated.2 forms of 150 (p150) and 120 kDa (p120) exist due to proteolytic degradation from a 180 kDa form.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	Q6YHK3