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Rabbit Anti-CASP2 Polyclonal Antibody#abs137119

Please be advised that the price provided is only for your reference. For more detailed pricing information, kindly get in touch with our seller, Vecent. Western blot analysis CASP2 using K562 whole cell lysates This product is for research use only, not for use in diagnostic prodecures or in...

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Description

Catalog-specification	Delivery time	USD price
abs137119-100ug	1-2 Weeks	301.0
abs137119-50ug	1-2 Weeks	201.0

Please be advised that the price provided is only for your reference. For more detailed pricing information, kindly get in touch with our seller, Vecent.

Overview
catalog	abs137119
Other names	Caspase 2, also known as CASP-2, Casp2, or CASP2_HUMAN, is an apoptosis-related cysteine peptidase that plays a vital role in the process of programmed cell death. This protein is also referred to as ICH 1, ICH 1 protease, ICH 1L, ICH1, ICH1 protease, ICH1L, NEDD-2, NEDD2, neural precursor cell-expressed developmentally down-regulated protein 2, PPP1R57, or protein phosphatase 1 regulatory subunit 57. Caspase 2 is a subunit p12 of Caspase-2 and is responsible for initiating the intrinsic apoptotic pathway. This protein coordinates the response to various cellular stresses and is involved in the regulation of both life and death signals. Caspase 2 has been linked to numerous cellular processes, including DNA damage, cellular senescence, immune surveillance, and tumorigenesis. In summary, Caspase 2 is a critical regulator of apoptosis and is involved in a variety of cellular processes. Its many aliases reflect the importance of this protein in the cell and its ability to coordinate responses to various stimuli, making it an attractive target for therapeutic intervention.
Source	Rabbit
Specificity	The total CASP2 levels in the body can be detected using the CASP2 antibody, which is specifically designed to identify endogenous amounts of this protein. This information is crucial for researchers who want to investigate the role of CASP2 in various biological processes. With the help of this antibody, precise and accurate measurements of total CASP2 can be obtained, which can be used to develop new therapeutic strategies to combat various diseases.
Species Reactivity	Human
Antigen	CASP2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CASP2.
MW	49 kDa
Properties
Concentration	1mg/ml
purification	The purifying process for the antiserum involved the use of SulfoLink™ Coupling Resin in peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	It is recommended to store at -20 °C for a duration of one year, while avoiding any freeze/thaw cycles.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline at pH 7.4, with 150mM NaCl and 0.02% sodium azide, as well as 50% glycerol to aid in storage. It is recommended to keep the solution at -20 °C for optimal stability, and it can remain stable for up to 12 months from the date of receipt.
Target
Background	Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.
Tissue specificity	Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle.
Posttranslational modification	The mature protease can process its own propeptide, but not that of other caspases.
Celluar localization	Cytosol;Mitochondrion;Nucleus;
UniPort	P42575