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Rabbit Anti-RHOQ Polyclonal Antibody#abs137120

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Description

Catalog-specification	Delivery time	USD price
abs137120-100ug	1-2 Weeks	301.0
abs137120-50ug	1-2 Weeks	201.0

Overview
catalog	abs137120
Other names	RAS homolog gene family member Q, also known as RAS-like family 7 member A or Ras-like protein family member 7A, is a small GTPase protein encoded by the RHOQ gene in humans. It is a member of the Ras-related protein family and closely related to the Ras-like protein TC10. RHOQ is involved in signaling pathways that regulate the actin cytoskeleton, cell adhesion, and cell migration. It is also implicated in the regulation of insulin-stimulated glucose uptake and the differentiation of adipocytes. The protein is highly conserved across species and has been studied extensively in various experimental models. Its role in human disease remains to be fully elucidated, though it has been implicated in cancer, cardiovascular disease, and other pathological conditions. Overall, RHOQ is a key regulator of cellular processes and a promising target for therapeutic intervention.
Source	Rabbit
Specificity	The RHOQ Antibody is capable of accurately detecting the natural levels of total RHOQ present in an organism's system. By utilizing this antibody, researchers can effectively analyze and study the overall expression of RHOQ protein without any interference. This detection method provides valuable insights into the intricate functioning and regulation of RHOQ in living organisms.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	RHOQ
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human RHOQ.
MW	25 kDa
Properties
Concentration	1mg/ml
purification	We employed SulfoLink™ Coupling Resin for peptide affinity chromatography to purify the antiserum. The purification process yielded a highly refined result.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to repeated freeze/thaw cycles.
Storage buffer	The storage conditions for Rabbit IgG include keeping it in phosphate buffered saline with a pH of 7.4 and a concentration of 150mM NaCl. Additionally, it should be mixed with 0.02% sodium azide and 50% glycerol. It is essential to store it at a temperature of -20 °C. This particular formulation remains stable for a period of 12 months starting from the date of receipt.
Target
Background	Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.
Posttranslational modification	May be post-translationally modified by both palmitoylation and polyisoprenylation.
Celluar localization	Cytoskeleton;Cytosol;Extracellular region or secreted;Golgi apparatus;Plasma Membrane;
UniPort	P17081