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Rabbit Anti-CD22 Polyclonal Antibody#abs137123

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Description

Catalog-specification	Delivery time	USD price
abs137123-100ug	1-2 Weeks	301.0
abs137123-50ug	1-2 Weeks	201.0

Overview
catalog	abs137123
Other names	The B cell receptor CD22 precursor, also known as the B lymphocyte cell adhesion molecule, BL CAM, or BLCAM, is a key molecule found on the surface of B cells. CD22 plays a crucial role in the regulation of B cell activation and function. This protein is also referred to as the CD22 antigen, CD22 molecule, or CD22 protein. Other names include Lectin 2, Leu14, Lyb8, MGC130020, sialic acid binding Ig like lectin 2, and sialic acid binding immunoglobulin like lectin 2. CD22 is a member of the SIGLEC family, which stands for sialic acid-binding Ig-like lectin. SIGLEC2, or Siglec-2, is another name for CD22. T cell surface antigen Leu 14 and T-cell surface antigen Leu-14 are also terms used to refer to CD22.
Source	Rabbit
Specificity	The CD22 Antibody is capable of detecting total CD22 levels that are present naturally within an organism. To create similar content, the information should be reorganized in a manner that still accurately reflects the original text.
Species Reactivity	Human
Antigen	CD22
Application	：WB1:1000-3000，IF/ICC1:100-1:500，ELISA(peptide)1:20000-1:40000。
Immunogen	A synthesized peptide derived from human CD22.
MW	95kDa
Properties
Concentration	1mg/ml
purification	Purification of the antiserum was accomplished using SulfoLink™ Coupling Resin through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Ensure that the product is stored at -20 °C for a duration of one year, taking care to avoid any instances of repeated freeze/thaw cycles.
Storage buffer	The rabbit IgG solution is formulated in phosphate buffered saline with a pH of 7.4, containing 150 millimolar of NaCl, 0.02% of sodium azide and 50% glycerol. It is recommended that this solution be stored at a temperature of -20 degrees Celsius and can be kept for up to 12 months from the date of receipt.
Target
Background	Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
Tissue specificity	B-lymphocytes.
Posttranslational modification	Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2.Phosphorylated on tyrosine residues by LYN.
Celluar localization	Extracellular region or secreted;Plasma Membrane;
UniPort	P20273