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Rabbit Anti-CAMK2A Polyclonal Antibody#abs137381

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Description

Catalog-specification	Delivery time	USD price
abs137381-100ug	1-2 Weeks	301.0
abs137381-50ug	1-2 Weeks	201.0

Overview
catalog	abs137381
Other names	Calcium-calmodulin dependent protein kinase II, also known as CaMKII, is a crucial player in signaling pathways that regulate a variety of cellular processes, including synaptic plasticity, learning and memory, and neuronal development. The alpha subunit of CaMKII is the most abundant, and it is encoded by the CAMK2A gene in humans. This protein is highly expressed in the brain, where it plays a critical role in the formation and maintenance of synaptic connections. CaMKII is activated by the binding of calcium and calmodulin, which induces autophosphorylation of the enzyme and leads to sustained activation. Dysregulation of CaMKII has been implicated in a range of neurological disorders, including Alzheimer's disease, epilepsy, and schizophrenia. Understanding the complex functions of CaMKII in the brain may provide novel insights into these devastating conditions and pave the way for the development of new treatments.
Source	Rabbit
Specificity	The total CAMK2A levels in a biological system can be accurately detected using the CAMK2A Antibody, which is capable of recognizing and binding to endogenous CAMK2A proteins.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	CAMK2A
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CAMK2A.
MW	54 kDa
Properties
Concentration	1mg/ml
purification	Through the use of SulfoLink™ Coupling Resin, peptide affinity chromatography was employed to purify the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity). Phosphorylates transcription factor FOXO3 on 'Ser-298' (PubMed:23805378). Activates FOXO3 transcriptional activity (By similarity).
Celluar localization	Cytosol;Mitochondrion;Nucleus;Plasma Membrane;
UniPort	Q9UQM7