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Rabbit Anti-CAMKK1 Polyclonal Antibody#abs139654

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Description

Catalog-specification	Delivery time	USD price
abs139654-100ug	1-2 Weeks	301.0
abs139654-50ug	1-2 Weeks	201.0

Overview
catalog	abs139654
Other names	Protein kinase kinase alpha, regulated by calcium and calmodulin; kinase that depends on calcium and calmodulin; alpha isoform of calcium/calmodulin-dependent protein kinase kinase 1; calcium/calmodulin-dependent protein kinase kinase 1; alpha isoform of calcium/calmodulin-dependent protein kinase kinase; calcium/calmodulin-dependent protein kinase kinase 1; alpha isoform of calcium/calmodulin-dependent protein kinase kinase; kinase regulated by Ca2+/calmodulin; kinase that phosphorylates CaM-kinase IV; kinase that activates CaM-kinase kinase 1; alpha isoform of CaM-kinase kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CaM-KK 1; CaM-KK alpha; CaMKK 1; CaMKK alpha; protein encoded by CAMKK alpha gene; CAMKK alpha isoform; CAMKK1 protein; protein coded by DKFZp761M0423 gene; KKCC1_HUMAN protein; MGC34095 protein; OTTMUSP00000006419 protein.
Source	Rabbit
Specificity	The total CAMKK1 present within the organism can be detected using the CAMKK1 Antibody. This antibody works by recognizing the endogenous levels of CAMKK1 and is therefore, highly specific for this target.
Species Reactivity	Human;Mouse;Rat
Antigen	CAMKK1
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CAMKK1.
MW	56 kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To preserve the integrity of the product, it should be kept at a temperature of -20 °C for a duration of one year. It is important to prevent the product from undergoing multiple freeze/thaw cycles to ensure that its efficacy is maintained. Please adhere to these storage guidelines to optimize the product's longevity.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Calcium/calmodulin-dependent protein kinase that belongs to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death.
Posttranslational modification	Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylated at multiple sites by PRCAKA/PKA. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin. In vitro, phosphorylated by CAMK1 and CAMK4 (By similarity).
Celluar localization	Cytosol;Nucleus;
UniPort	Q8N5S9