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Rabbit Anti-CADPS2 Polyclonal Antibody#abs138831

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Description

Catalog-specification	Delivery time	USD price
abs138831-100ug	1-2 Weeks	301.0
abs138831-50ug	1-2 Weeks	201.0

Overview
catalog	abs138831
Other names	Calcium-dependent activator protein for secretion 2, also known as Cadps2 or Calcium-dependent secretion activator 2, is a protein encoded by the KIAA1591 gene. This protein is involved in the regulation of calcium-dependent neurotransmitter release and has been implicated in neurodevelopmental disorders. Cadps2 plays an important role in the release of synaptic vesicles, which are responsible for the communication between neurons. It is widely expressed in the central nervous system and has diverse functions, including modulation of synaptic plasticity and dendritic spine morphology. Understanding the function of Cadps2 can help elucidate the underlying mechanisms of various neurological and psychiatric disorders.
Source	Rabbit
Specificity	The CADPS2 Antibody is capable of detecting total CADPS2 at its endogenous levels. This information can be rearranged to say that total CADPS2 at its endogenous levels can be detected using the CADPS2 Antibody.
Species Reactivity	Human;Rat
Antigen	CADPS2
Application	WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
Immunogen	A synthesized peptide derived from human CADPS2.
MW	148kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	Make sure to store the product at -20 °C for a duration of one year to maintain its quality. It is important to avoid subjecting it to repeated freeze/thaw cycles during this period.
Storage buffer	This product contains Rabbit IgG in a solution of phosphate buffered saline (pH 7.4), 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is suggested that it be stored at -20 °C and is stable for up to one year from the date of receipt.
Target
Background	This protein, which binds calcium, plays a crucial role in the exocytosis of vesicles that contain neurotransmitters and neuropeptides. It is believed to function upstream of fusion in the formation or maintenance of mature secretory vesicles. Additionally, it controls the release of neurotrophins from granule cells, thereby influencing cell differentiation and survival during the development of the cerebellum. It may have a specific role in facilitating the calcium-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles. In short, this calcium-binding protein is involved in various processes related to vesicle trafficking and neurotransmitter release.
Tissue specificity	Widely expressed. Expressed in all adult and fetal tissues examined, with the strongest expression in kidney and pancreas. In brain, it is expressed at high levels in cerebellum, to a lesser degree in cerebral cortex, occipital pole, and frontal and temporal lobes. Only weakly expressed in medulla, spinal cord and putamen.
Celluar localization	Nucleus;Plasma Membrane;
UniPort	Q86UW7