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Rabbit Anti-BDNF Polyclonal Antibody#abs135907

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Description

Catalog-specification	Delivery time	USD price
abs135907-100ug	1-2 Weeks	301.0
abs135907-50ug	1-2 Weeks	201.0

Overview
catalog	abs135907
Description	During development, neurotrophins play a crucial role in regulating the natural cell death of neurons. The first identified neurotrophin, nerve growth factor (NGF), was discovered in the 1950s as a soluble peptide that promotes the survival and growth of neurons in sympathetic ganglia. Over time, three other neurotrophic factors with similar structures have been identified: brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4 or NT-5). These neurotrophins have been found to stimulate the survival of different populations of neurons in laboratory studies, with some overlap between their effects. The specific cell surface receptors through which neurotrophins exert their actions have also been identified. For example, NGF primarily binds to the Trk A receptor, but it can also bind to NT-3 and NT-4. The Trk B receptor, on the other hand, binds both BDNF and NT-4 equally well, and to a lesser extent, NT-3. The Trk C receptor specifically binds to NT-3. In summary, neurotrophins, such as NGF, BDNF, NT-3, and NT-4, play a vital role in regulating neuronal cell death during development. These neurotrophins bind to specific receptors on the surface of neurons, promoting their survival and growth. Understanding the functions and interactions of neurotrophins and their receptors is essential for comprehending the intricate processes underlying neuronal development and maintenance.
Other names	The following terms all pertain to a key protein in the brain known as Brain-derived neurotrophic factor, or BDNF for short. Other names for this protein include Abrineurin, ANON2, BULN2, MGC34632, and Neurotrophin. BDNF is a critical player in the growth, survival, and maintenance of neurons in the brain, and has been implicated in a range of neurological and psychiatric disorders. Its importance to brain health and function make it an important target for research and potential therapeutic interventions.
Source	Rabbit
Specificity	The BDNF Antibody is capable of detecting total levels of endogenous BDNF within the body. To generate content with a highly similar meaning, the information from the original text can be re-arranged and written in different words.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Zebrafish;Chicken;Rabbit;Xenopus;Dog;Horse;Bovine;Sheep;Pig
Antigen	BDNF
Application	1:500-1:2000，1:50-1:200，1:100-1:500，（）1:20000-1:40000。
Immunogen	A synthesized peptide derived from human BDNF.
MW	28kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Tissue specificity	Brain. Highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. Also expressed in heart, lung, skeletal muscle, testis, prostate and placenta.
Posttranslational modification	The propeptide is N-glycosylated and glycosulfated.Converted into mature BDNF by plasmin (PLG).
Celluar localization	Extracellular region or secreted;Mitochondrion;Nucleus;
UniPort	P23560