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Rabbit Anti-Cleaved Caspase-1 (Arg317) /P10 Polyclonal Antibody#abs143596

Rabbit Anti-Cleaved Caspase-1 (Arg317) /P10 Polyclonal Antibody#abs143596

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. It's important to understand that our seller can provide you with all the specifics you need and answer any questions you may have. Therefore, we...

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Description

Catalog-specificationDelivery timeUSD price

abs143596-50ug

1-2 Weeks

201.0

abs143596-100ug

1-2 Weeks

301.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our seller, Vecent. It's important to understand that our seller can provide you with all the specifics you need and answer any questions you may have. Therefore, we highly encourage you to reach out to Vecent for more information regarding pricing.


Overview

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abs143596
Other namesCASP-1, also known as Caspase-1 or IL-1 beta-converting enzyme, is a critical enzyme involved in the regulation of inflammation and immune responses. The enzyme exists as a heterodimer composed of a large and small subunit, with the smaller subunit being the p10. CASP-1 plays a crucial role in the processing and activation of the cytokine, IL-1beta, responsible for initiating and promoting inflammatory responses.
Additionally, CASP-1 is involved in the maturation and secretion of other inflammatory cytokines, such as IL-18, and is critical in the initiation of pyroptosis, a form of programmed cell death. Dysregulation of CASP-1 has been implicated in various diseases, including autoimmune disorders, cardiovascular disease, and neurodegenerative diseases.
Therefore, elucidating the role of CASP-1 in mediating inflammatory responses holds promise in developing targeted therapies for the treatment of various inflammatory disorders. Understanding the mechanisms underlying its function and regulation is fundamental to harnessing its potential as a therapeutic target and unlocking new avenues for the treatment of inflammatory diseases.
SourceRabbit
SpecificityThe antibody for Caspase 1 (p10, Cleaved-Arg317) can identify and measure the levels of a specific fragment of activated Caspase 1. This fragment is formed as a result of cleavage occurring adjacent to Arg317. Its detection allows for the assessment of the endogenous levels of this active form of Caspase 1 in biological samples.
Species ReactivityHuman;Mouse;Rat
AntigenCleaved Caspase-1 /P10
ApplicationFor Western Blotting, we recommend diluting the antibody at a range of 1:500-1:2000. For Immunohistochemistry, a dilution of 1:50-1:200 is suitable. If you plan to utilize the antibody for Immunofluorescence or Immunocytochemistry, please follow the recommended dilution range of 1:100-1:500. Lastly, for ELISA using peptide, we suggest a dilution range of 1:20000-1:40000. Please take note that these are just guidelines and may vary depending on the sample and experimental conditions.
ImmunogenA synthesized peptide derived from human Caspase 1 was utilized in the production of an antiserum. The resulting antiserum is highly specific and effectively targets Caspase 1.
MW10kDa
Properties

Concentration

1mg/ml

purificationUsing SulfoLink™ Coupling Resin, the purification of the antiserum was carried out through peptide affinity chromatography.
ClonalityPolyclonal Antibody
Stability & StorageThis product should be stored at a temperature of -20 °C to ensure its longevity. It is stable for a period of 12 months from the date of receipt. Rest assured that this product will meet your requirements and maintain its shelf life when stored properly.
Storage bufferThe Rabbit IgG comes in a solution of phosphate buffered saline with a pH of 7.4, 150mM NaCl, and 0.02% sodium azide, and it is supplemented with 50% glycerol for storage at -20 °C. It is stable for a period of 12 months from the date of receipt, making it a reliable choice for your research needs.

Target

Tissue specificityExpressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Posttranslational modificationThe two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Celluar localizationCytoplasm.
UniPortP29466


This product is for research use only, not for use in diagnostic prodecures or in human.


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