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Rabbit Anti-Cleaved-IL-1 Beta (Asp116) Polyclonal Antibody#abs143595

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Description

Catalog-specification	Delivery time	USD price
abs143595-50ug	1-2 Weeks	201.0
abs143595-100ug	1-2 Weeks	301.0

Overview
catalog	abs143595
Other names	Beta-interleukin 1, also known as IL-1 beta or IL1B, is a protein involved in the immune system. It is associated with the activation of inflammatory responses and plays a role in various physiological processes. IL-1 beta is encoded by the IL1B gene and is produced as a precursor molecule known as pro-interleukin 1 beta. During inflammation, pro-interleukin 1 beta is processed to form the mature interleukin 1 beta protein, which is responsible for triggering inflammatory reactions. IL-1 beta is also known as catabolin, H1, or OAF and is classified as IL-1F2. Its coding sequence is designated as OTTHUMP00000162031.
Source	Rabbit
Specificity	The IL1Î² (Cleaved-Asp116) Antibody is capable of detecting levels of a specific fragment of activated IL1Î² protein that has been cleaved adjacent to Asp116, a process which occurs naturally within the body. This antibody is designed to target and latch on to the cleaved fragment, allowing scientists to measure and track levels of this specific form of IL1Î² within biological samples. As a result, this powerful scientific tool can provide invaluable insights into the mechanisms and activity of this important cytokine within the body.
Species Reactivity	Human;Mouse;Rat
Antigen	Cleaved-IL-1 Î²
Application	For Western blotting, the recommended dilution range is between 1:500 to 1:2000, for immunohistochemistry the range is between 1:50 to 1:200, for immunofluorescence or immunocytochemistry the range is between 1:100 to 1:500, and for ELISA with peptide antigens the range is between 1:20000 to 1:40000. These dilution ranges provide optimal results for detecting specific target proteins or peptides in various experimental applications. It is important to follow the recommended dilution ranges to ensure accurate and reliable results for your experiments.
Immunogen	The human IL1 beta-derived synthesized peptide was used to produce the antiserum. The generated content should be highly similar to the original text information, but it should be rearranged and presented in a different manner.
MW	17 kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, we were able to purify the antiserum through peptide affinity chromatography. Our process involved carefully isolating and extracting the desired components to ensure a high level of purity and efficacy.
Clonality	Polyclonal Antibody
Stability & Storage	The recommended storage temperature for this product is -20 Â°C. It is important to note that this product is stable for up to 12 months from the date of receipt when stored under these conditions. It is crucial to adhere to the storage instructions to ensure the product's effectiveness and longevity.
Storage buffer	This particular Rabbit IgG solution is specifically formulated to be stored in a phosphate buffered saline mixture with a pH level of 7.4. Additionally, the solution includes 150mM of sodium chloride, 0.02% of sodium azide, and 50% of glycerol to ensure stability. To maintain the solution's integrity, it must be stored at a freezing temperature of -20°C. The IgG solution can be used for up to 12 months from the date of receipt.
Target
Background	Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells.
Tissue specificity	Expressed in activated monocytes/macrophages (at protein level).
Posttranslational modification	Activation of the IL1B precursor involves a CASP1-catalyzed proteolytic cleavage. Processing and secretion are temporarily associated.
Celluar localization	Lysosome;Cytosol;Extracellular region or secreted
UniPort	P01584

This product is for research use only, not for use in diagnostic prodecures or in human.

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