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Rabbit Anti-APOC2 Polyclonal Antibody#abs136127

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent. Western blot analysis of extracts of variouscell lines, using APOC2 antibody. This product is for research use only, not for use in...

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Description

Catalog-specification	Delivery time	USD price
abs136127-100ug	1-2 Weeks	301.0
abs136127-50ug	1-2 Weeks	201.0

Please note that the price mentioned above is only for your reference. For detailed pricing information, kindly get in touch with our sales representative, Vecent.

Overview
catalog	abs136127
Description	This apolipoprotein gene family member encodes a lipid-binding protein that plays a crucial role in lipid metabolism. It is responsible for the transportation of lipids in the bloodstream as part of very low density lipoprotein. Additionally, this protein has the ability to activate lipoprotein lipase, an enzyme that breaks down triglycerides into free fatty acids for cellular utilization. However, mutations in this gene have been identified to cause a condition known as hyperlipoproteinemia type IB. This disorder is characterized by abnormally high levels of triglycerides in the blood, leading to the development of xanthomas, increased risk of pancreatitis, and early onset of atherosclerosis. Interestingly, this gene is located on chromosome 19 along with other closely related apolipoprotein genes, forming a cluster. There exists a natural occurrence of read-through transcription between this gene and its adjacent upstream gene, apolipoprotein C-IV (APOC4). This signifies the potential for co-regulation and coordination between these genes in lipid homeostasis. In summary, this gene's role in lipid metabolism, its association with hyperlipoproteinemia type IB, and its genomic location within a cluster of apolipoprotein genes emphasize its significance in maintaining lipid balance and overall cardiovascular health.
Other names	The protein known as APC2 has several other names, such as APC2, Apo CII, APOC 2, ApoC II, APOC2, and APOC2 protein. It is also referred to as APOC2_HUMAN, ApoCII, Apolipoprotein C II, Apolipoprotein C II precursor, Apolipoprotein C2, ApolipoproteinCII, and MGC75082. To provide a highly similar content, let's rearrange the above information while maintaining the original text: Apolipoprotein C II, also called APC2, Apo CII, APOC 2, or ApoC II, is a protein with various names, including APOC2, APOC2 protein, APOC2_HUMAN, ApoCII, Apolipoprotein C II precursor, Apolipoprotein C2, ApolipoproteinCII, and MGC75082.
Source	Rabbit
Specificity	The APOC2 Antibody is capable of detecting the total amount of endogenous APOC2 present in the sample. The antibody is designed to specifically recognize and bind with APOC2 protein and provides a reliable way to quantify APOC2 levels.
Species Reactivity	Human;Mouse;Rat
Antigen	APOC2
Application	Here are some rearranged versions of the original content: 1. For Western blotting, dilute the antibody at a ratio of 1:500 to 1:2000. When using immunohistochemistry, dilute the antibody at a ratio of 1:50 to 1:200. For ELISA assays using peptides, dilute the antibody at a ratio of 1:20000 to 1:40000. 2. We recommend diluting the antibody for Western blotting in a range of 1:500 to 1:2000. If you plan to use it for immunohistochemistry, dilute the antibody at a ratio of 1:50 to 1:200. For ELISA assays using peptides, dilute the antibody at a ratio of 1:20000 to 1:40000. 3. To prepare for Western blotting, dilute the antibody in a 1:500 to 1:2000 ratio. For immunohistochemistry, use a dilution of 1:50 to 1:200. ELISA assays using peptides require dilution at a ratio of 1:20000 to 1:40000. 4. Dilute the antibody for Western blotting at a ratio of 1:500 to 1:2000, or use a dilution of 1:50 to 1:200 for immunohistochemistry. When performing ELISA assays with peptides, dilute the antibody at a ratio of 1:20000 to 1:40000. 5. For optimal results in Western blotting, dilute the antibody at a ratio of 1:500 to 1:2000. Immunohistochemistry requires a dilution of 1:50 to 1:200, and ELISA assays using peptides should be performed with a dilution of 1:20000 to 1:40000.
Immunogen	A synthesized peptide derived from human APOC2.
MW	11kDa
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar sentence could be: The process of peptide affinity chromatography was utilized to purify the antiserum, with SulfoLink™ Coupling Resin playing a critical role in the procedure.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL.
Tissue specificity	Liver and intestine.
Posttranslational modification	Proapolipoprotein C-II is synthesized as a sialic acid containing glycoprotein which is subsequently desialylated prior to its proteolytic processing.Proapolipoprotein C-II, the major form found in plasma undergoes proteolytic cleavage of its N-terminal hexapeptide to generate apolipoprotein C-II, which occurs as the minor form in plasma.
Celluar localization	Endosome;Extracellular region or secreted;
UniPort	P02655