Rabbit Anti-CRBP III Polyclonal Antibody #abs130531

abs130531-50ug

1-2 Weeks

201

abs130531-100ug

1-2 Weeks

301

Description

RBP5 is a member of the calycin superfamily and belongs to the Fatty-acid binding protein (FABP) family. It is involved in the intracellular transport of retinol. This protein plays an essential role in the absorption and transportation of Vitamin A, which is crucial for maintaining healthy vision, immune function, and skin health. RBP5 acts as a shuttle protein, binding to retinol in the bloodstream, and transporting it to target tissues where it can be stored or used. This protein is critical for maintaining adequate levels of Vitamin A in the body, which is essential for overall health and wellbeing.

Other names

Cellular retinol-binding protein III, also known as CRBP III or RBP5, is a crucial protein that helps transport the essential nutrient retinol (vitamin A) throughout the body. This protein is highly important in various biological processes, such as vision, gene expression, and cellular differentiation, amongst others. CRBP III is also referred to as CRBP-III, CRBP3, CRBPIII, HRBPiso, and Retinol-binding protein 5. It is encoded by the OTTHUMP00000238163 gene and is widely researched because of its crucial role in the human body. Understanding the functions of CRBP III can help scientists develop new treatments and therapies for various illnesses and medical conditions related to vitamin A deficiency.

Source

Rabbit

Specificity

The CRBP III Antibody is capable of identifying CRBP III levels within the body. This is due to its ability to react with endogenous proteins, which are naturally produced by the body. By utilizing this antibody, researchers can better understand the role that CRBP III plays in various physiological processes. It is crucial to ensure that the generated content is unique and not simply a rearrangement of the original text.

Species Reactivity

Human

Application

The recommended dilutions for immunohistochemistry (IHC) are 1:50-1:200, while for immunofluorescence/immunocytochemistry (IF/ICC) it is suggested to use dilutions of 1:100-1:500. For ELISA using peptide as an antigen, the recommended dilutions are 1:20000-1:40000. It is important to carefully follow these dilution guidelines for optimal results in your experiments.

Immunogen

A synthesized peptide derived from human CRBP III

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To maintain the quality of the product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid exposing the product to repeated freeze and thaw cycles, as this could potentially affect its effectiveness and potency. Taking these precautions will help ensure that the product remains stable and effective for its intended use.

Storage buffer

The rabbit IgG solution is composed of phosphate buffered saline with pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. It is recommended to store the solution at -20 °C for optimal preservation. It has been proven to be stable for 12 months from the date of receipt. It is crucial to handle and store this solution with care to prevent damage and degradation of the product.

Target

Background

Intracellular transport of retinol.

Tissue specificity

The expression of this gene is higher in adult kidney and liver, and to a lesser extent in adult and fetal spleen, adult lymph nodes and appendix, and fetal liver and kidney. However, in hepatocellular carcinoma tissues, the expression of this gene is strongly decreased at the protein level. It is crucial to note that these findings suggest that this gene plays an important role in the normal functioning of the aforementioned organs and tissues. Nonetheless, further research is needed to fully understand the implications of the decreased expression of this gene in hepatocellular carcinoma tissues.

Celluar localization

Extracellular region or secreted;

UniPort

P82980