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Rabbit Anti-APBB1IP Polyclonal Antibody#abs137313

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Description

Catalog-specification	Delivery time	USD price
abs137313-100ug	1-2 Weeks	301.0
abs137313-50ug	1-2 Weeks	201.0

Overview
catalog	abs137313
Other names	PREL1 (Proline rich EVH1 ligand 1), also known as APBB1 interacting protein 1 or Amyloid beta precursor protein binding family B member 1, is a crucial protein involved in interactions with the amyloid beta A4 precursor protein. It is encoded by the gene AB1IP and is also referred to as Amyloid beta A4 precursor protein binding family B member 1 interacting protein or INAG1. PREL1, also known as RARP1 (Retinoic acid responsive proline rich protein 1) or Proline rich protein 73, plays a significant role as a Rap1 GTP interacting adapter molecule. It functions as an adaptor molecule for RAP1, facilitating its interactions with various cellular components. The multifaceted nature of PREL1 underscores its importance in various cellular processes, particularly those associated with amyloid beta precursor protein binding and retinoic acid responsiveness. These collaborations with key molecules make PREL1 an intriguing target for further exploration in the fields of Alzheimer's disease and cancer research. Its diverse interactions contribute to its functional diversity and potential implications in disease pathogenesis. In summary, PREL1, a versatile protein, interacts with amyloid beta A4 precursor protein, participates in Rap1 GTP signaling, and responds to retinoic acid stimulation. The intricate network of interactions involving PREL1 highlights its significance in cellular physiology and warrants further investigation.
Source	Rabbit
Specificity	The total levels of endogenous APBB1IP can be detected by using APBB1IP Antibody. It is important to note that this antibody is capable of detecting the complete APBB1IP protein.
Species Reactivity	Human;Mouse
Antigen	APBB1IP
Application	Our Western blot dilution ratio ranges from 1:1000 to 1:3000. For immunofluorescence and immunocytochemistry, the recommended dilution is between 1:100 and 1:500. In the case of ELISA using peptide antigens, a dilution ratio of 1:20000 to 1:40000 is commonly used.
Immunogen	A synthesized peptide derived from human APBB1IP.
MW	100 kd
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was utilized in the peptide affinity chromatography purification of the antiserum. This resulted in the production of a highly purified and effective antiserum product.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is crucial to avoid subjecting the product to repeated freeze/thaw cycles as it may affect its quality.
Storage buffer	The provided information is about Rabbit IgG stored in a solution of phosphate buffered saline (pH 7.4), containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It should be stored at a temperature of -20 °C and is considered stable for a period of 12 months from the date of receipt.
Target
Background	Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion.
Tissue specificity	Widely expressed with high expression in thymus, spleen, lymph node, bone marrow and peripheral leukocytes.
Celluar localization	Cytoskeleton;Cytosol;Plasma Membrane;
UniPort	Q7Z5R6