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Rabbit Anti-HDAC11 Polyclonal Antibody#abs133264

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Description

Catalog-specification	Delivery time	USD price
abs133264-100ug	1-2 Weeks	301.0
abs133264-50ug	1-2 Weeks	201.0

Overview
catalog	abs133264
Other names	Histone deacetylase 11, also known as HDAC11 or HDA11_HUMAN, is a protein that belongs to the HDAC family. Its gene is called FLJ22237, and it is located on human chromosome 3p25.3. HDAC11 is involved in the regulation of gene expression and cellular signaling pathways, and it plays an important role in various biological processes such as cell differentiation, development, and immune responses. Its function is to remove acetyl groups from histones, which changes the structure of chromatin and affects gene expression. As such, HDAC11 is an attractive target for therapeutic interventions, particularly in the treatment of cancer and other diseases associated with aberrant gene expression.
Source	Rabbit
Specificity	The HDAC11 Antibody is capable of detecting the total amount of endogenous HDAC11 present in a sample. This means that the antibody can accurately measure the levels of HDAC11 without any interference or cross-reactivity from other proteins. The use of this antibody is particularly useful in research studies where the activity of HDAC11 is being investigated, as it provides a precise measurement of the protein levels in the sample. By detecting the endogenous levels of HDAC11, researchers can gain a better understanding of the function and regulation of this important protein in various biological processes.
Species Reactivity	Human
Predictive reaction species	Pig;Rabbit;Sheep;Dog;Bovine;Horse;
Antigen	HDAC11
Application	: WB1:1000-3000，IF/ICC1:100-1:500，ELISA（）1:20000-1:40000。，。
Immunogen	A synthesized peptide derived from human HDAC11.
MW	39kDa
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to perform peptide affinity chromatography for purifying the antiserum.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain its quality, it is recommended to store the product at a temperature of -20 °C for a duration of one year. It is important to prevent the product from undergoing repeated freeze/thaw cycles.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline with a pH of 7.4. The solution should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of Rabbit IgG is guaranteed for a period of 12 months starting from the date of receipt.
Target
Background	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.
Tissue specificity	Weakly expressed in most tissues. Strongly expressed in brain, heart, skeletal muscle, kidney and testis.
Celluar localization	Extracellular region or secreted;Nucleus;Plasma Membrane;
UniPort	Q96DB2