Rabbit Anti-ANKRD1 Polyclonal Antibody #abs130505

abs130505-50ug

1-2 Weeks

201

abs130505-100ug

1-2 Weeks

301

Description

The nucleus of endothelial cells is where the protein encoded by this gene is localized, and its expression is triggered by IL-1 and TNF-alpha stimulation. Experimental findings in rat cardiomyocytes suggest that this gene acts as a transcription factor.

Other names

ANKR1_HUMAN, also known as Ankyrin repeat domain 1 (cardiac muscle) or Ankyrin repeat domain-containing protein 1, is a protein encoded by the ANKRD1 gene. It is also referred to as bA320F15.2, C 193, C193, Cardiac ankyrin repeat protein, CARP, CVARP, Cytokine inducible nuclear protein, Cytokine-inducible gene C-193 protein, Cytokine-inducible nuclear protein, HA1A2, liver ankyrin repeat domain 1, MCARP, and OTTHUMP00000020084.
ANKR1_HUMAN belongs to the ankyrin repeat domain-containing protein family and plays a vital role in cardiac muscle. It is characterized by the presence of ankyrin repeat domains, which are conserved protein motifs involved in protein-protein interactions. These repeat domains allow ANKR1_HUMAN to interact with various partners and participate in multiple cellular processes.
ANKR1_HUMAN is known to be induced by cytokines, hence its alternative name cytokine-inducible nuclear protein. It is involved in modulating gene expression and has been implicated in the regulation of cardiac development and function. It is also expressed in other tissues, including the liver.
The importance of ANKR1_HUMAN in cardiac muscle is highlighted by its association with various cardiovascular diseases. Dysregulation of ANKR1_HUMAN expression has been observed in conditions such as heart failure, myocardial infarction, and hypertrophy. It is believed that ANKR1_HUMAN may be involved in the remodeling processes of the heart in response to stress or injury.
In summary, ANKR1_HUMAN, also known as ANKRD1 or cardiac ankyrin repeat protein, is a versatile protein that plays a crucial role in cardiac muscle and is involved in various cellular processes. Its dysregulation has been implicated in cardiovascular diseases, making it a potential target for therapeutic interventions.

Source

Rabbit

Specificity

The ANKRD1 Antibody is designed to specifically recognize and bind to the ANKRD1 protein at its endogenous levels. This antibody can be used for various biochemical and molecular studies to investigate the functions and characteristics of ANKRD1. By detecting the endogenous levels of ANKRD1, researchers can gain valuable insights into the role this protein plays in cellular processes and its potential implications in disease mechanisms.

Species Reactivity

Human;Mouse;Rat

Application

WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Immunogen

A synthesized peptide derived from human ANKRD1

Properties

Concentration

1mg/ml

Purification

Immunogen affinity purified

Clonality

Polyclonal Antibody

Stability & Storage

To ensure optimal storage conditions, it is recommended to store at a temperature of -20 °C for a duration of one year. It is important to avoid exposing the product to repeated cycles of freeze and thaw, as this could compromise its quality and effectiveness. Please ensure strict adherence to these guidelines for the best possible results.

Storage buffer

This product is Rabbit IgG in a solution of phosphate buffered saline with a pH value of 7.4, 150mM of NaCl, 0.02% sodium azide, and 50% glycerol. It should be kept at a temperature of -20 °C and is stable for a period of 12 months from the date of receipt. We strongly advise you to follow these instructions to ensure the continued quality of the product.

Target

Background

Endothelial cell activation could potentially be influenced by May, as it may hold a crucial role in this process. Additionally, it is speculated that this factor might function as a nuclear transcription factor, capable of negatively regulating the expression of specific genes associated with the heart. Interestingly, the emergence of this factor appears to exhibit a strong correlation with apoptotic cell death in hepatoma cells.

Tissue specificity

The primary expression of the gene is observed in activated vascular endothelial cells, while it is also found, to a lesser degree, in hepatoma cells. Let me generate a highly similar content by rearranging the given information. Please note that the generated content will still follow the original text's context and details, but its structure and wording may be different.
Vascular endothelial cells predominantly exhibit the expression of this gene upon activation. In addition, its presence can also be detected, albeit to a lesser extent, in hepatoma cells.

Celluar localization

Cytosol;Nucleus;

UniPort

Q15327