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Rabbit Anti-AGTRL1 Polyclonal Antibody#abs135155

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Description

Catalog-specification	Delivery time	USD price
abs135155-100ug	1-2 Weeks	301.0
abs135155-50ug	1-2 Weeks	201.0

Overview
catalog	abs135155
Other names	AGTR L1, also known as AGTRL1 or Angiotensin II receptor like 1, is a protein that functions as a receptor for Angiotensin II. It is also referred to as the Angiotensin receptor-like 1 or Apelin receptor. Other names include APJ (apelin) receptor, APJ, APJ receptor, APJ_HUMAN, APJR, APLNR, B78, FLJ90771, G protein coupled receptor APJ, G-protein coupled receptor APJ, G-protein coupled receptor HG11, GPCR34, HG11, HG11 orphan receptor, MGC45246, and MSR or msr/apj. This protein is involved in several physiological processes, including the regulation of blood pressure and cardiovascular function. It belongs to the G protein-coupled receptor (GPCR) family, which plays a crucial role in signal transmission across the cell membrane. Understanding the function and mechanism of AGTR L1 can have important implications for the development of pharmaceutical drugs targeting the renin-angiotensin system and cardiovascular diseases. Further research is required to explore its potential as a therapeutic target.
Source	Rabbit
Specificity	The AGTRL1 Antibody is able to identify the total AGTRL1 present within the body at its natural levels. To clarify, this antibody specifically recognizes and binds to endogenous AGTRL1. Thus, it has the capability to accurately detect and measure the overall amount of AGTRL1 within biological samples.
Species Reactivity	Human
Antigen	AGTRL1
Application	Sure, here's a rearranged version of the original content: For Western Blotting (WB), the recommended dilution range is 1:500 to 1:1000. When it comes to Immunofluorescence/Immunocytochemistry (IF/ICC), the suggested dilution is 1:100 to 1:500. As for ELISA using peptide antigens, the optimal dilution range is typically between 1:20000 and 1:40000.
Immunogen	A synthesized peptide.
MW	43 KD
Properties
Concentration	1mg/ml
purification	The SulfoLink™ Coupling Resin was utilized to purify the antiserum through peptide affinity chromatography.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure optimal storage conditions, maintain a temperature of -20 °C for a duration of one year. It is crucial to avoid subjecting the stored items to repeated cycles of freezing and thawing.
Storage buffer	The recommended storage conditions for Rabbit IgG are as follows: it should be stored at a temperature of -20°C. The solution should be prepared in phosphate-buffered saline with a pH of 7.4. In addition to this, it should contain 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that this product has a shelf life of 12 months from the date of receipt. Make sure to adhere to these guidelines to ensure the stability and efficacy of the Rabbit IgG.
Target
Background	Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936). Plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity). Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility, and heart failure by acting as a receptor for APLN hormone (PubMed:25639753, PubMed:28137936).
Tissue specificity	Expressed in heart, brain, kidney, stomach, spleen, thymus, lung, ovary, small intestine and colon, adipose tissues and pancreas (PubMed:8294032, PubMed:25639753). Expressed in glial cells, astrocytes and neuronal subpopulations (PubMed:8294032). Expressed in embryonic (ESCs) and induced (iPSCs) pluripotent stem cells (PubMed:25639753).
Celluar localization	Plasma Membrane;
UniPort	P35414