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Rabbit Anti-GDI1 Polyclonal Antibody#abs136864

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Description

Catalog-specification	Delivery time	USD price
abs136864-100ug	1-2 Weeks	301.0
abs136864-50ug	1-2 Weeks	201.0

Overview
catalog	abs136864
Description	Proteins known as GDP dissociation inhibitors play a crucial role in regulating the GDP-GTP exchange reaction of rab family members, which are small GTP-binding proteins that are integral to the process of vesicular trafficking between cellular organelles. By slowing the rate of GDP dissociation from rab proteins and releasing GDP from membrane-bound rabs, GDIs are able to exert significant control over this important mechanism. GDI1 is largely confined to neural and sensory tissues, and mutations within this protein have been linked to X-linked nonspecific mental retardation.
Other names	GDI-1, also known as FLJ41411 or gdi1, is a protein encoded by the GDIA_HUMAN gene. It is also referred to as GDP dissociation inhibitor 1 or Guanosine diphosphate dissociation inhibitor 1. Additionally, it has been associated with certain medical conditions such as Mental retardation X-linked 41, Mental retardation X-linked 48, or Oligophrenin 2. The protein, also known as GDIL or OPHN2, is involved in regulating the dissociation of guanosine diphosphate (GDP) from Rab GTPases. It plays a crucial role in vesicular trafficking and intracellular signaling. Another name for GDI-1 is Protein XAP 4 or Protein XAP-4. It is a part of the RABGD1A family and is commonly referred to as Rab GDP dissociation inhibitor alpha or RABGDIA. In summary, GDI-1, also known as FLJ41411 or gdi1, is a crucial protein involved in vesicular trafficking and intracellular signaling. It is associated with various medical conditions such as mental retardation and oligophrenin. Additionally, it is a part of the Rab GDP dissociation inhibitor alpha protein family, also known as RABGDIA.
Source	Rabbit
Specificity	The GDI1 Antibody is capable of specifically recognizing and detecting the total endogenous levels of GDI1 protein. To provide detailed information, the content has been rearranged while still maintaining the key elements from the original text.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Zebrafish;Rabbit;Pig;Dog;Horse;Bovine;Sheep;
Antigen	GDI1
Application	For Western Blot applications, the recommended dilution range is between 1:500 and 1:2000. For immunohistochemistry, a dilution range between 1:50 and 1:200 is suggested. As for ELISA assays using peptides, the recommended dilution range is between 1:20000 and 1:40000. These dilutions have been optimized to ensure accurate and reproducible results. It is important to follow the recommended dilution guidelines to obtain the best possible results from your experiments.
Immunogen	A synthesized peptide derived from human GDI1.
MW	55kDa
Properties
Concentration	1mg/ml
purification	The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin .
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes.
Tissue specificity	Brain; predominant in neural and sensory tissues.
Celluar localization	Cytosol;Golgi apparatus;
UniPort	P31150