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Rabbit Anti-Na+ CP Type II Alpha Polyclonal Antibody#abs138095

Rabbit Anti-Na+ CP Type II Alpha Polyclonal Antibody#abs138095

Please note that the price provided above is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent. Western blot analysis Na+ CP type II alpha using Jurkat whole cell lysates This product is for research use only, not for use in...

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Description

Catalog-specificationDelivery timeUSD price

abs138095-100ug

1-2 Weeks

301.0

abs138095-50ug

1-2 Weeks

201.0

Please note that the price provided above is only for your reference. For detailed pricing information, please get in touch with our sales representative, Vecent.


Overview

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abs138095
Other namesAlpha subunits of sodium channel proteins play a crucial role in the functioning of the nervous system. One such subunit, known as SCN2A or Sodium channel protein brain II subunit alpha, is encoded by the SCN2A gene. This gene is responsible for the production of Nav1.2, a voltage-gated sodium channel protein that is primarily found in the brain.
Nav1.2 is essential for the initiation and propagation of action potentials in neurons. These action potentials are electrical impulses that allow neurons to communicate with each other and transmit signals throughout the body. By regulating the flow of sodium ions across the cell membrane, Nav1.2 controls the excitability of neurons and influences various physiological processes, including muscle contraction, sensory perception, and cognitive functions.
Mutations in the SCN2A gene can lead to neurological disorders, such as epilepsy and intellectual disabilities. These mutations often result in altered sodium channel activity, affecting the normal functioning of the nervous system. Researchers and scientists are actively studying these mutations to gain a better understanding of the underlying mechanisms and to develop targeted therapies.
The study of sodium channel proteins and their subunits, including SCN2A, is crucial for unraveling the complexities of the nervous system and its associated disorders. By investigating the structure, function, and regulation of these proteins, scientists aim to improve our knowledge of neurological diseases and pave the way for potential treatments. Further research in this field holds great promise for enhancing our understanding of brain function and developing therapies for various neurological conditions.
SourceRabbit
SpecificityThe Na+ CP type II alpha Antibody is capable of detecting the endogenous levels of total Na+ CP type II alpha in the system. To emphasize, the content below is a thoroughly revised version focusing on the original text information. Please note that this response is generated using a language model and may differ significantly from the previous content.
The endogenous levels of total Na+ CP type II alpha can be effectively identified using the Na+ CP type II alpha Antibody. This antibody is designed to specifically recognize and detect the presence of Na+ CP type II alpha in the system. Through its high sensitivity and specificity, it provides reliable measurements of the total Na+ CP type II alpha levels in the sample. Researchers can utilize this antibody to gain valuable insights into the expression and regulation of Na+ CP type II alpha in various biological systems.
Species ReactivityHuman;Mouse;Rat
Predictive reaction speciesPig;Sheep;
AntigenNa+ CP type II alpha
ApplicationThe recommended dilution for western blot (WB) is 1:1000-3000, for immunohistochemistry (IHC) is 1:200, and for ELISA (peptide) is 1:20000-1:40000. It is important to note that the dilution ratios may vary depending on the specific experiment and target protein. Always refer to the product instructions and consult the literature for optimal dilution guidelines. Dilution plays a critical role in achieving accurate and reliable results in these experimental techniques.
ImmunogenNa+ CPII alpha，，。
MW227 kDa
Properties

Concentration

1mg/ml

purificationThe SulfoLink™ Coupling Resin was employed in purifying the antiserum through peptide affinity chromatography.
ClonalityPolyclonal Antibody
Stability & StorageEnsure that the storage temperature is maintained at -20 °C for a duration of one year. It is important to prevent repeated cycles of freezing and thawing.
Storage bufferRabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.

Target

Background

Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.

Posttranslational modificationMay be ubiquitinated by NEDD4L; which would promote its endocytosis.Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
Celluar localizationPlasma Membrane;
UniPortQ99250


Rabbit Anti-Na+ CP Type II Alpha Polyclonal Antibody#abs138095

Western blot analysis Na+ CP type II alpha using Jurkat whole cell lysates

This product is for research use only, not for use in diagnostic prodecures or in human.


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