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Rabbit Anti-Rab 11B Polyclonal Antibody#abs140527

Description

Catalog-specification	Delivery time	USD price
abs140527-100ug	1-2 Weeks	301.0
abs140527-50ug	1-2 Weeks	201.0

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Overview
catalog	abs140527
Other names	Protein Ypt3 belongs to the GTP-binding protein family. It is also known as Rab11B, which is a member of the RAS oncogene family. Ypt3 is a Ras-related protein that plays a crucial role in cellular processes. In humans, this protein is encoded by the RB11B gene. Ypt3 is involved in the regulation of intracellular trafficking and vesicular transport. It is a key player in the coordination of membrane trafficking and recycling pathways. By rearranging the given content, we can create a highly similar version of the information.
Source	Rabbit
Specificity	The Rab 11B Antibody is capable of detecting the total amounts of endogenous Rab 11B present in the sample. By rearranging the original content, a highly similar statement is created that emphasizes the antibody's ability to recognize and measure the levels of Rab 11B. It highlights the fact that the antibody can detect Rab 11B present within the sample, without any alterations or modifications.
Species Reactivity	Human;Rat
Predictive reaction species	Pig;Sheep;Dog;Bovine;
Antigen	Rab 11B
Application	For western blotting, a dilution of 1:1000 is recommended. Immunohistochemistry works best with a dilution of 1:200. For immunofluorescence or immunocytochemistry, it is recommended to use a dilution range of 1:100-1:500. When working with ELISA using a peptide, a dilution of 1:20000-1:40000 is recommended for best results. It is important to carefully follow recommended dilution ratios to ensure accurate and reliable results in each experiment.
Immunogen	A synthesized peptide derived from human Rab 11B.
MW	28kDa
Properties
Concentration	1mg/ml
purification	The purified antiserum went through peptide affinity chromatography, utilizing SulfoLink™ Coupling Resin for the process.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the longevity of this product, it is recommended to store it at a temperature of -20 °C for up to one year. It is important to avoid subjecting the product to frequent freeze and thaw cycles, as this can affect its quality. So, if you want to keep your product in good condition, make sure to follow these storage guidelines.
Storage buffer	The storage conditions for Rabbit IgG are as follows: it should be stored at -20°C in phosphate buffered saline with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is important to note that the stability of the product is guaranteed for 12 months from the date of receipt.
Target
Background	The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis.
Tissue specificity	Up-regulated by extracellular acidosis and down-regulated by alkalosis (at protein level).
Posttranslational modification	Citrullinated by PADI4.
Celluar localization	Cytosol;Endosome;Extracellular region or secreted;Mitochondrion;
UniPort	Q15907