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Rabbit Anti-5-HT-3A Polyclonal Antibody#abs133804

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Description

Catalog-specification	Delivery time	USD price
abs133804-100ug	1-2 Weeks	301.0
abs133804-50ug	1-2 Weeks	201.0

Overview
catalog	abs133804
Other names	The 5-HT3 receptor, also known as the 5-HT3A receptor or the 5-hydroxytryptamine receptor 3A, is a serotonin-gated ion channel receptor. It is commonly referred to as the 5-HT3 receptor, 5-HT3-A, or 5-HT3R. This receptor plays a crucial role in various physiological processes within the body. It is involved in the transmission of signals in the central nervous system and plays a role in mediating nausea, vomiting, and anxiety. The HTR3 gene encodes the 5-HT3A receptor, and its expression has been observed in various tissues, including the brain, gastrointestinal tract, and spinal cord. Understanding the function and pharmacology of the 5-HT3 receptor is important in the development of therapeutic strategies targeting this receptor for various conditions and disorders.
Source	Rabbit
Specificity	The total 5-HT-3A levels in the body can be detected using the 5-HT-3A antibody, which specifically targets the endogenous 5-HT-3A protein.
Species Reactivity	Human
Antigen	5-HT-3A
Application	For Western blotting, a dilution ratio of 1:500 to 1:1000 is recommended, while for immunofluorescence or immunocytochemistry, a dilution range of 1:100 to 1:500 is suggested. When performing ELISA using peptides, a dilution ratio of 1:20000 to 1:40000 is appropriate. It is important to follow these guidelines to ensure accurate and reliable results.
Immunogen	A synthesized peptide.
MW	55 KD
Properties
Concentration	1mg/ml
purification	Using SulfoLink™ Coupling Resin, the antiserum underwent purification through peptide affinity chromatography. A highly similar content can be created by rearranging the structure of the original text, while still conveying the same information.
Clonality	Polyclonal Antibody
Stability & Storage	To maintain the integrity of the product, it is recommended to store it at a temperature of -20 °C for a period of one year. It is important to note that the product should not be subjected to repeated freezing and thawing cycles as this could compromise its efficacy. Therefore, it is advisable to handle the product with care during storage to ensure its optimal performance.
Storage buffer	The stability of Rabbit IgG is guaranteed for 12 months from the date of receipt when stored at -20 °C. It is formulated in a phosphate buffered saline solution with a pH of 7.4, containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. It is recommended to store the product under these conditions to maintain its quality.
Target
Background	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
Tissue specificity	Expressed in cerebral cortex, amygdala, hippocampus, and testis. Detected in monocytes of the spleen and tonsil, in small and large intestine, uterus, prostate, ovary and placenta.
Celluar localization	Plasma Membrane;
UniPort	P46098