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Rabbit Anti-14-3-3 Eta Polyclonal Antibody#abs133794

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Description

Catalog-specification	Delivery time	USD price
abs133794-100ug	1-2 Weeks	301.0
abs133794-50ug	1-2 Weeks	201.0

Overview
catalog	abs133794
Other names	The 14-3-3 protein eta, also known as YWHA1 or tyrosine 3/tryptophan 5 monooxygenase activation protein eta polypeptide, is a brain protein that plays a vital role in various cellular processes. It belongs to the family of 14-3-3 proteins, which are highly conserved proteins that are found in all eukaryotic organisms. The 14-3-3 protein eta isoform is encoded by the YWHA1 gene, which is located on chromosome 22q12.1. The 14-3-3 protein eta acts as a regulatory protein that interacts with numerous signaling molecules and modulates their function. It is involved in several cellular pathways, including cell cycle control, apoptosis, and protein trafficking. The protein interacts with various kinases, phosphatases, and transcription factors, thereby controlling their activity and subcellular localization. The YWHA1 gene is ubiquitously expressed in most tissues, but its expression is particularly high in the brain. The protein is involved in several neurological disorders, including schizophrenia and Alzheimer's disease. Recent studies have also implicated the 14-3-3 protein eta in the pathogenesis of various types of cancer. In summary, the 14-3-3 protein eta is a critical regulatory protein that plays a vital role in various cellular processes. Its diverse functions make it an exciting target for therapeutic intervention in several neurological and oncological disorders.
Source	Rabbit
Specificity	The endogenous levels of total 14-3-3 η can be accurately detected using the 14-3-3 η Antibody.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Chicken;Rabbit;Pig;Dog;Sheep;Horse;Bovine
Antigen	14-3-3 eta
Application	WB 1:500~1:1000，IF/ICC 1:100-1:500，ELISA(peptide) 1:20000-1:40000。。WB1:5001:1000，IF/ICC1:1001:500。，ELISA (peptide)1:200001:40000。。
Immunogen	A synthesized peptide.
MW	42 KD
Properties
Concentration	1mg/ml
purification	To obtain a concentrated and purified antiserum, peptide affinity chromatography was employed with the use of SulfoLink™ Coupling Resin.
Clonality	Polyclonal Antibody
Stability & Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Tissue specificity	Expressed mainly in the brain and present in other tissues albeit at lower levels.
Posttranslational modification	Phosphorylated on Ser-59 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.
Celluar localization	Cytosol;Extracellular region or secreted;Mitochondrion;Plasma Membrane;
UniPort	Q04917