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Rabbit Anti-14-3-3 Gamma Polyclonal Antibody#abs133795

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Description

Catalog-specification	Delivery time	USD price
abs133795-100ug	1-2 Weeks	301.0
abs133795-50ug	1-2 Weeks	201.0

Overview
catalog	abs133795
Other names	Gamma isoform of 14-3-3 protein, also known as protein kinase C inhibitor protein 1 (KCIP-1) or tyrosine 3 monooxygenase/tryptophan 5 monooxygenase activation protein gamma polypeptide (Ywhag), is a subtype of the 14-3-3 protein family. This protein is encoded by the 1433G_HUMAN gene and is involved in a variety of cellular processes, including signal transduction, protein phosphorylation, and cell cycle regulation. The N-terminally processed 14-3-3 protein gamma is highly conserved among different species, indicating its essential role in cellular function. It has been shown to interact with a multitude of proteins, including kinases, phosphatases, transcription factors, and cytoskeletal proteins. Research has revealed that 14-3-3 protein gamma is involved in the development of various diseases, such as cancer, neurodegenerative disorders, and cardiovascular diseases. Therefore, understanding the functions and mechanisms of this protein may provide insights into the pathogenesis of these illnesses and the development of new therapeutic strategies. In summary, 14-3-3 protein gamma is a crucial protein involved in multiple cellular processes and is essential for the proper functioning of the body. Further studies on this protein may provide new avenues for the treatment of various pathologies.
Source	Rabbit
Specificity	The endogenous levels of total 14-3-3 γ can be detected using the 14-3-3 γ antibody. It is capable of identifying the presence of 14-3-3 γ protein at its natural levels. By utilizing this antibody, researchers can accurately measure the amount of total 14-3-3 γ in a biological sample.
Species Reactivity	Human;Mouse;Rat
Predictive reaction species	Xenopus;Chicken;Rabbit;Pig;Dog;Horse;Bovine
Antigen	14-3-3 γ
Application	For western blot, the recommended dilution range is 1:500 to 1:1000. The optimal dilution range for immunohistochemistry is 1:50 to 1:200. The dilution range for immunofluorescence and immunocytochemistry is 1:100 to 1:500. For ELISA with peptide, the suggested dilution range is between 1:20000 and 1:40000. It is essential to follow these recommended dilutions to achieve optimal results.
Immunogen	A synthesized peptide.
MW	28 KD
Properties
Concentration	1mg/ml
purification	SulfoLink™ Coupling Resin was employed to carry out peptide affinity chromatography for the purification of the antiserum. Please provide a highly analogous rendition of the given information while ensuring that the generated content is rooted in the original text details. It is crucial to refrain from engaging in a dialogue format like the one facilitated by ChapGPT, and instead, focus on generating speech that is distinct from the language model's manner of output.
Clonality	Polyclonal Antibody
Stability & Storage	To ensure the preservation of the item, it should be stored at a temperature of -20 °C for a period of one year. It is important to avoid subjecting it to repeated freeze/thaw cycles.
Storage buffer	Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt.
Target
Background	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Tissue specificity	Highly expressed in brain, skeletal muscle, and heart.
Posttranslational modification	Phosphorylated by various PKC isozymes.
Celluar localization	Cytosol;Extracellular region or secreted;Mitochondrion;
UniPort	P61981