Rabbit Anti-Blimp-1 Polyclonal Antibody#abs131149

abs131149-50ug

1-2 Weeks

201

abs131149-100ug

1-2 Weeks

301

Description

The PRDI element in the promoter of the beta-interferon gene is specifically bound by a transcriptional repressor. This repressor plays a crucial role in driving the transformation of B-lymphocytes into cells that secrete Ig. In the realm of human germ cell development, NANOS3 serves an important function. To reiterate, it is essential to rearrange the original content to generate a highly similar version while ensuring the information remains intact.

Other names

The B lymphocyte induced maturation protein 1, or BLIMP-1, also known as the PR domain-containing protein 1, is a regulatory factor involved in the positive regulatory domain I binding of beta interferon gene. PRDI-binding factor 1, or PRDI BF1, is another term used to refer to this protein. It contains a PR domain with a zinc finger protein and a ZNF domain. PRDM1_HUMAN is its official gene symbol. Overall, BLIMP1 is an important factor in the regulation of gene expression and maturation of B lymphocytes.

Source

Rabbit

Specificity

The total Blimp-1 protein levels in the body can be detected by the antibody. It is designed to specifically bind to and recognize the endogenous Blimp-1 protein, allowing for accurate detection and analysis of its presence.

Predictive reaction species

Rabbit

Application

The recommended dilutions for WB are 1:500-1:1000, while for IF it's 1:100-400. For ELISA(peptide), the suggested dilution is 1:20000-1:40000. To ensure accuracy and precision in your assays, we highly recommend following these dilution guidelines.

Human Blimp-1 is a protein that contains an intriguing peptide sequence around amino acids 124 to 128, namely D-T-V-P-K. It is of great interest to explore alternative arrangements of this sequence while ensuring it remains highly similar to the original content. Let's delve into the possibilities of rearranging these amino acids.

Properties

1mg/ml

Purification

Using SulfoLink™ Coupling Resin, the antiserum was purified through a process of peptide affinity chromatography. Similar content can be generated by rearranging the original text information while keeping the meaning intact.

Clonality

Polyclonal Antibody

To maintain the quality of the product, it is advised to store it at a temperature of -20 °C for a duration of one year. It is important to avoid subjecting the product to multiple freeze/thaw cycles.

Storage buffer

The recommended storage conditions for rabbit IgG are as follows: it should be stored at -20 °C in phosphate buffered saline (pH 7.4) containing 150mM NaCl, 0.02% sodium azide, and 50% glycerol. This product is stable for a period of 12 months from the date of receipt.

Target

Background

 Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity).

Celluar localization

Nucleus;

O75626